The fourth episode starts off with the two riding through Santa Cruz, Argentina. The plan is to cross over into Chile and then going up into the Andes. Ewan and Charley head through Argentina’s red rock landscape while a member of their team copes with altitude sickness. The duo are well and truly underway and the first signs of all are well is how well the Harleys hold up in challenging conditions. The roads alternate between unforgiving and pleasant and these e-bikes push through effortlessly. As they ride through Chilean Andes, the audience is shown a picturesque view of the beauty of the countryside, an experience which Boorman calls 'magical.'

As the journey continues, there's beauty and danger in equal measure for Charley Boorman and Ewan McGrego. The duo ride their electric Harleys through the exotic and breathtaking Bolivian countryside in a tough ascent. The sixth episode showcases some of the challenges the hosts and the crew face when they scale the terrain. One of the Rivians runs into trouble while sandy roads and a heavy breeze sees Boorman take a tumble. Apart from all the accidents, the chapter also shows some quality work done by UNICEF when it comes to educating and working with the children in Bolivia.
The altitude sickness hits Taylor, their logistics man real bad and McGregor starts feeling it as well. The episode ends with a doctor heading to his hotel room to check up on him.

Across the universe, galaxies are going dark, and scientists don't know why the stars are losing their shine. Something is slowly drawing the curtains closed on the universe. Our milky way is under threat. Astronomers race against time to uncover the truth behind how galaxies are born and how they die before all of the lights go out.

COVID-19 is far from the first pandemic to wreak havoc in the world. A long line of infectious diseases have devastated and in some cases destroyed entire societies. Almost all of them started in animals and made the jump to humans. The Black Death spread across Europe and Asia in the 14th century leaving millions dead in its wake. Between the 15th and 18th centuries, European colonists brought smallpox to the Americas, the Pacific region and to Australia. In Europe, the 17th century saw a series of major epidemics. And at the end of the First World War, more people died of the Spanish flu than on the battlefield.
This documentary examines the causes of these epidemics - whether it be lack of hygiene, interaction with animals, overcrowding, or the growth of cities - and how people travelling helped to spread disease and promote pandemics. It also sheds a light on the impact these infectious diseases have had on politics and societal change. Over the centuries, scientists managed to develop treatments and medicines to help control or even eradicate infectious diseases. Virologists are facing that task again with the coronavirus, as the world frantically searches for ways to overcome a pandemic which threatens our modern way of life.

Most planets we know of are so hellish, it seems impossible that anything could live. But it's amazing where life can take hold in the Earth. Astrobiologists look for simple single-celled microbes known as extremophiles in places as Danakil Depression, known in Ethiopia as 'The Gateway to Hell.'
In Episode 2, the fictional world is Janus, a planet in such a close orbit than its rotation is locked by the star's gravity and it always shows the same face to its sun. On one side of the planet, it's always daytime, a searing desert. On the other side, it's forever night, a frozen shadowland. Squeezed between the two, a sliver of perpetual twilight. Freezing meltwater flows from the cold side, carving canyons through the landscape. Deep in these canyons lives an extraordinary five-legged creature.

Planets beyond our solar system are known to astronomers as exoplanets. They are at trillions of miles from Earth and yet, it might be possible to detect a faint signature of life in them. From the light of the stars they orbit that passes through the atmosphere of an exoplanet, it is possible to capture the chemical fingerprint of the elements in that atmosphere.
The fictional world Eden is orbiting not one star, but two. The light from its twin stars powers photosynthesis, pumping more oxygen into the atmosphere than in Earth, allowing life to thrive. Grazers are constantly alert to danger, because the canopy is home to predators perfectly evolved to live among the trees. In Episode 3, another topic are fungi and the role they could play on exoplanets. Ecologist Thomas Crowther talks about the role mycelial networks play in the Rothiemurchus forest in Scotland.