The Milky Way, our galaxy, is a magnificent sight in the night sky, but we know surprisingly little about it for certain. What is its shape? How many stars does it actually contain? What lies at its centre? The Gaia space telescope will answer these questions, being armed with the most advanced camera to leave our planet, and it will allow us to see our galaxy as we've never seen it before. The Sky at Night visits the factory in Chelmsford that made the astonishing sensor at the heart of the mission.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

The black hole at the centre of the Milky Way is getting ready to feast. A gas cloud three times the size of our planet has strayed within the gravitational reach of our nearest supermassive black hole. And across the globe, telescopes are being trained on the heart of our Milky Way galaxy, some 27,000 light years from Earth, in the expectation of observing this unique cosmic spectacle. For cosmic detectives across the Earth, it is a unique opportunity. For the first time in the history of science, they hope to observe in action the awesome spectacle of a feeding supermassive black hole.

Adam Rutherford meets a new creature created by American scientists, the spider-goat. It is part goat, part spider, and its milk can be used to create artificial spider's web. It is part of a new field of research, synthetic biology, with a radical aim: to break down nature into spare parts so that we can rebuild it however we please. This technology is already being used to make bio-diesel to power cars. Other researchers are looking at how we might, one day, control human emotions by sending 'biological machines' into our brains.

An exploration of Earth's cosmic neighbourhood. Looking beyond the borders of our solar system, what's nearby in our galaxy? How do the other objects in our local area influence life on Earth? And, how did Earth's place in the galaxy make it the perfect place for the development of advanced life? Now that the Voyagers have visited the outer planets of the solar system they are heading for new adventures in places astronomers call the Oort Cloud, the heliopause, heliosheath and eventually they may encounter double stars and exoplanets, some of which may pay a visit to the solar system one day or explode showering us with radiation. If the Voyagers live so long they will experience the local fluff, local bubble and other parts of the habitable zone of the galaxy.