It's 3.5 million years ago and in East Africa a remarkable species of ape roams the land. Australopithecus afarensis has taken the first tentative steps towards humanity by standing and walking on two legs. The rift valley was forming, and the rain forests dying as Africa dried out - turning the landscape into a mosaic of scattered trees and grass. In this new environment afarensis found it more efficient to move about on two legs rather than four.

'Blood Brothers' follows the lives of two species, Paranthropus boisei and Homo habilis who embody two alternative ways of ape-man life. Although heavyset, with distinctive gorilla-like faces, the boisei are gentle characters. They live within a strict social structure and are led by a dominant male whose strength and power holds the group together. The habilis have taken a different approach to survival. They don't have the specialisms of the boisei but instead have developed into the archetypal jack-of-all-trades, inquisitive scavengers prepared to try almost anything to survive. Tough, active, gregarious and noisy, they are always on the move and always alert to the possibility of a meal. But in the near drought of the dry season the habilis are struggling. It seems as if their way of life cannot help them when conditions are tough.

One and a half million years ago, a new breed of ape-man walks the land. In southern Africa, Homo Ergaster has taken the next step to becoming human. They have long, modern looking noses, which cool air as they breathe. Their hairless bodies, with millions of tiny sweat glands, mean they don't pant anymore to control their temperature - they sweat. And, above all, they have big brains - nearly two-thirds the size of ours.

Nearly half a million years ago, the most advanced human yet roams Europe. Strong and powerful, Homo heidelbergensis are fierce hunters, use sophisticated tools and live in close-knit family groups. Over 200,000 years they become split into two populations by extremes of weather and environment and evolve separately into two very different species. In the North are the Neanderthals, whose physical power and resilience is the key to surviving in ice age Northern Europe. About 140,000 years ago, Africa is in the grip of a devastating drought, and something remarkable has happened to the descendants of heidelbergensis who live there. The combination of environment and chance has bred in them a unique ability that will change the course of human history. It will be this small band of southern survivors, perhaps numbering just a few tens of thousands, who will come to dominate the world and be known as Homo sapiens.

The first episode looks at how birds first took to the skies in the wake of the insects. It begins in Mexico, where Sir Attenborough observes bats being outmanoeuvred by a red-tailed hawk. Pterosaurs were the birds' forerunners, some 150 million years after dragonflies developed the means of flight, but eventually went extinct together with the dinosaurs. Birds had by then already evolved from early forms like archaeopteryx, the first creature to possess feathers. Its ancestry can be traced through reptiles, and some current species, such as the flying lizard, possibly show paths this evolution may have taken." One of the biggest birds to have ever existed was the terror bird, which proliferated after dinosaurs vanished and stood up to 2.5 metres tall. By comparison, the ostrich, while not closely related, is the largest and heaviest living bird. It was probably the evasion of predators that drove most birds into the air, so their flightless cousins evolved because they had few enemies. Accordingly, such species are more likely to be found on islands, and Sir Attenborough visits New Zealand to observe its great variety, most especially the kiwi. Also depicted is the moa, another huge creature that is now gone. The takahē is extremely rare, and high in the mountains of New Zealand, Sir Attenborough discovers one from a population of only 40 pairs. Finally, another example on the brink of extinction is the kakapo, which at one point numbered only 61 individuals. A male is heard calling — an immensely amplified deep note that can be heard at great distances from its nest.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).