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On a spectacular journey through Renaissance Italy, Andrew Graham-Dixon searches for the shadowy figure who wrote one of the most important books on art and looks at some dazzling works, including masterpieces of the early Renaissance by Giotto, Masaccio and Donatello. Giorgio Vasari was the grandaddy of all art critics, travelling Italy in the 16th century for his definitive Lives of the Artists. It was a time of miracles that he named 'the Renaissance'.

Black Holes are one of the most destructive forces in the universe, capable of tearing a planet apart and swallowing an entire star. Yet scientists now believe they could hold the key to answering the ultimate question - what was there before the Big Bang? The trouble is that researching them is next to impossible. Black holes are by definition invisible and there's no scientific theory able to explain them. Meet the astronomers attempting to image a black hole for the very first time and the theoretical physicists getting ever closer to unlocking their mysteries. It's a story that takes us into the heart of a black hole and to the very edge of what we think we know about the universe.

'In Search of Beethoven': takes a comprehensive look at the composer's life through historical research and Beethoven's biography and letters, but with the emphasis always on the performance -- and interpretation -- of Beethoven's music. From his early piano concertos through the "Moonlight Sonata," "Für Elise," and the immortal notes of the Fifth and Ninth Symphonies, Beethoven's music remains as beloved, popular, and relevant as any work of art has ever been. "In Search of Beethoven" brings together the world's leading performers and experts on Beethoven to reveal new insights into this celebrated composer.

Above all, 'In Search of Beethoven' addresses the central myth of Beethoven's life and work -- that of the heroic, tormented figure battling to overcome the tragic fate of being struck down by deafness in his prime; a man who searched for his elusive, eternal 'immortal beloved,' yet was never to attain lasting happiness.

The drug policies have remained unchanged over the last 40 years so should they be reformed in the light of new research? Recent research has analysed the link between the harmful effects of drugs relative to their current classification by law with some startling conclusions. Perhaps most startling of all is that alcohol, solvents and tobacco (all unclassified drugs) are rated more dangerous than ecstasy, 4-MTA and LSD (all class A drugs).

We are in the grip of an allergy epidemic. 50 years ago one in 30 were affected, but in Britain today it is closer to one in three. Why this should be is one of modern medicine's greatest puzzles. In search of answers, Horizon travels round the globe, from the remotest inhabited island to the polluted centres of California and the UK. We meet sufferers and the scientists who have dedicated their lives trying to answer the mystery of why we are becoming allergic to our world.