The Universe as we know it is condemned to death. Space, matter and even time will one day cease to exist and there's nothing we can do about it. Harsh realities are revealed about the future of our Universe; it may collapse and burn or it might be gripped by a galactic ice age. Either of these scenarios might be a long way off. However, our Universe could suddenly be destroyed by a "random quantum fluctuation", a bubble of destruction that can obliterate the entire cosmos in the blink of an eye. No matter how it ends, life in our Universe is doomed.

In space travel there is a saying that the first 50 miles and the last 50 miles are the most dangerous. Explore the controlled explosion of launch, the fiery crucible of re-entry and everything in between. See how a single spark inside a spacecraft or a micrometeoroid less than an inch wide hitting a space station can turn a routine mission into a lethal nightmare. As the missions become longer, venturing to Mars and beyond, the potential disasters will only become bigger. What would happen if a spacecraft ventured too close to a black hole or was hit by a gamma ray burst?

As man moves to colonize the cosmos, the realities of sexual relationships and reproduction need to be addressed. Probe the physiological, psychological and cultural challenges of sex in space.

In the third episode we will see Europe by the 17th century taking over from the Middle East as the powerhouse of mathematical ideas. Great strides had been made in understanding the geometry of objects fixed in time and space. The race was on to discover the mathematics to describe objects in motion. This programme explores the work of Rene Descartes, Pierre Fermat, Isaac Newton, Leonard Euler and Carl Friedrich Gauss. Du Sautoy proceeds to describes René Descartes realisation that it was possible to describe curved lines as equations and thus link algebra and geometry. He talks with Henk J. M. Bos about Descartes. He shows how one of Pierre de Fermat’s theorems is now the basis for the codes that protect credit card transactions on the internet. He describes Isaac Newton’s development of math and physics crucial to understanding the behaviour of moving objects in engineering. He covers the Leibniz and Newton calculus controversy and the Bernoulli family. He further covers Leonhard Euler, the father of topology, and Gauss' invention of a new way of handling equations, modular arithmetic. The further contribution of Gauss to our understanding of how prime numbers are distributed is covered thus providing the platform for Bernhard Riemann's theories on prime numbers. In addition Riemann worked on the properties of objects, which he saw as manifolds that could exist in multi-dimensional space.

Take an express journey to the edge of the universe as the filmmakers use computer-generated animation to build on images captures by the Hubble Telescope. The animation and story telling absolutely wonderful. Beginning on planet Earth, viewers are hurtled into the deepest reaches of space. There are no stops on this flight, and along the way the mysteries of the universe come alive as we examine the history and science of distant celestial.

In the last in the series Professor Jim Al-Khalili explores how studying the atom forced us to rethink the nature of reality itself. He discovers that there might be parallel universes in which different versions of us exist, finds out that empty space isn't empty at all, and investigates the differences in our perception of the world in the universe and the reality.