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A journey through the cosmos in search of alien life. We seek out planets around distand stars and dive into the oceans of other worlds - seeking an answer to the question: is there anybody out there?

The documentary 'The Knowledge of Healing' is an illuminating examination of Tibetan medicine, a practice which has developed over two millennia into a modern day successful method of healing that rivals western medical practices. Unlike Western medicine, based on biochemistry, Tibetan medical thinking (which is strongly rooted in Buddhist principles) views the human body as governed by an elaborately organized system of energies flowing through a network of channels. In the 12th century, the Gyüshi (Knowledge of Healing) was created, a text codifying this intricate system. The medications used comprise herbs, roots, minerals, etc. After flourishing for centuries, most Tibetan medical schools were destroyed by the Chinese in the 1950's and 1960's, and many physicians were executed. Speaking from exile, the Dalai Lama argues for the value of Tibetan medicine, while his personal physician Dr. Tenzin Choedrak describes the principles behind it. We follow physicians in India and Siberia treating patients for a variety of ailments from paralysis to heart disease, and meet researchers in Israel and Switzerland to see how western clinical studies are testing the effectiveness of Tibetan medicine.

The episode, devoted to the planet Mars, begins with scientific and fictional speculation about the Red Planet during the late nineteenth and early twentieth centuries (H. G. Wells' The War of the Worlds, Edgar Rice Burroughs' science fiction books, and Percival Lowell's false vision of canals on Mars). It then moves to Robert Goddard's early experiments in rocket-building, inspired by reading science fiction, and the work by Mars probes, including the Viking, searching for life on Mars. The episode ends with the possibility of the terraforming and colonization of Mars and a Cosmos Update on the relevance of Mars' environment to Earth's and the possibility of a manned mission to Mars.

Ideas about time and space are explored in the changes that constellations undergo over time, the redshift and blue shift measured in interstellar objects, time dilation in Albert Einstein's theory of relativity, the designs of both Leonardo da Vinci and spacecraft that could travel near light speed, time travel and its hypothetical effects on human history, the origins of the Solar System, the history of life, and the immensity of space. In Cosmos Update, the idea of faster-than-light travel by wormholes (researched by Kip Thorne and shown in Sagan’s novel Contact) is discussed.

Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

Questions are raised about the search for intelligent life beyond the Earth, with UFOs and other close encounters refuted in favor of communications through SETI and radio telescope such as the Arecibo Observatory. The probability of technically advanced civilizations existing elsewhere in the Milky Way is interpreted using the Drake equation and a future hypothetical Encyclopedia Galactica is discussed as a repository of information about other worlds in the galaxy. The Cosmos Update notes that there have been fewer sightings of UFOs and more stories of abductions, while mentioning the META scanning the skies for signals.