Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

This episodes the nature of the cosmos on the micro and atomic scales, using the Ship of the Imagination to explore these realms. Tyson describes some of the micro-organism that live within a dew drop, demonstrating parameciums and tardigrades. He proceeds to discuss how plants use photosynthesis via their chloroplasts to convert sunlight into chemical reactions that convert carbon dioxide and water into oxygen and energy-rich sugars. Tyson then discusses the nature of molecules and atoms and how they relate to the evolution of species. He uses the example set forth by Charles Darwin postulating the existence of the long-tongued Morgan's sphinx moth based on the nature of the comet orchid with pollen far within the flower. He further demonstrates that scents from flowers are used to trigger olfactory centers in the brain, stimulating the mind to threats as to aid in the survival of the species. Tyson narrates how Greek philosophers Thales and Democritus postulated that all matter was made up of combinations of atoms in a large number of configurations, and describes how carbon forms the basic building block for life on earth due to its unique chemical nature. Tyson explains on the basic atomic structure of protons, neutrons, and electrons, and the nature of nuclear fusion that occurs in most stars. He then discusses the existence of neutrinos that are created by these nuclear processes in stars, and that detecting such sub-atomic particles which normally pass through matter require subterranean facilities like the Super-Kamiokande that were used to detect neutrinos from the supernova SN 1987A in the Large Magellanic Cloud before light from the explosion were observed due to their ability to pass through matter of the dying sun. Tyson compares how neutrinos were postulated by Wolfgang Pauli to account for the conservation of energy from nuclear reactions in the same manner as Darwin's postulate on the long-tongued moth. Tyson concludes by noting that there are neutrinos from the Big Bang still existing in the universe but due to the nature of light, there is a "wall of infinity" that cannot be observed beyond.

This episode explores the palaeogeography of Earth over millions of years, and its impact on the development of life on the planet. Tyson starts by explaining that the lignin-rich trees evolved in the Carboniferous era about 300 million ago, then explains on the nature of plate tectonics that would shape the landmasses of the world and the asteroid impact that initiated the Cretaceous–Paleogene extinction event, leaving small mammals as the dominate species on earth. Earth's landmasses are expected to change in the future and postulates what may be the next great extinction event.

This episode explores the nature of the greenhouse effect (discovered by Joseph Fourier and Svante Arrhenius), and the evidence demonstrating the existence of global warming from humanity's influence. Tyson begins by describing the long-term history of the planet Venus; based on readings from the Venera series of probes to the planet, the planet had once had an ocean and an atmosphere, but due to the release of carbon dioxide from volcanic eruptions, the runaway greenhouse effect on Venus caused the surface temperatures to increase and boiled away the oceans. Tyson then notes the delicate nature of the amount of carbon dioxide in the atmosphere can influence Earth's climate due to the greenhouse effect, and that levels of carbon dioxide have been increasing since the start of the 20th century. Evidence has shown this to be from mankind's consumption of oil, coal, and gas instead of from volcanic eruptions due to the isotopic signature of the carbon dioxide. The increase in carbon dioxide has led to an increase in temperatures, in turn leading to positive feedback loops of the melting polar ice caps and dethawing of the permafrost to increase carbon dioxide levels. Tyson then notes that humans have discovered means of harvesting solar power, such as Augustin Mouchot's solar-driven motor in the 19th century, and Frank Shuman's solar-based steam generator in the 1910's. Tyson points out that in both cases, the economics and ease of using cheap coal and oil caused these inventions to be overlooked at the time. Today, solar and wind-power systems would be able to collect enough solar energy from the sun easily. Tyson then compares the motivation for switching to these cleaner forms of energy to the efforts of the Space race and emphasizes that it is not too late for humanity to correct its course.

Tyson describes the discovery of cosmic rays by Victor Hess through high-altitude balloon trips. Swiss Astronomer Fritz Zwicky, in studying supernovae, postulated that these cosmic rays originated from these events instead of electromagnetic radiation. Also tells how Vera Rubin observed that the rotation of stars at the edges of observable galaxies did not follow expected rotational behavior leading to consider the existence of dark matter. This further led to the discovery of dark energy to account for the increasing rate of expansion of the universe. Tyson then describes the interstellar travel of the two Voyager probes. Tyson tells the Carl Sagan's role in the Voyager program, including creating the Voyager Golden Record to encapsulate humanity and Earth's position in the universe. Tyson concludes the series by emphasizing Sagan's message on the human condition in the vastness of the cosmos, and to encourage viewers to continue to explore and discover what else the universe has to offer.

Bitcoin is a peer-to-peer monetary system in which all transaction records are public. Participants can use its open-source software to transfer virtual currency to one another as easily as they might send an email. Bitcoin opens an uncharted world of new possibilities to explore. We'll follow the stories of entrepreneurs and startups that are helping shape the new financial frontier. We'll look at the competitive mining market and the various subcultures within the Bitcoin community." You'll encounter a variety of characters and opinions as we examine the social and political impact of an open-source digital currency. Will the rise of Bitcoin bring a monetary paradigm shift that will forever change the world? Supposedly invented by a mysterious Japanese man named Satoshi Nakamoto (whose current whereabouts are unknown). Because it is designed to have an absolute ceiling of 21 million Bitcoins in circulation (not anticipated until 2040), and the system has no central depository or administrative authority, it has great appeal to libertarians and others who seek alternatives to a perceived corrupt, manipulative banking infrastructure and excessive government regulations. Its low processing fees compared with those of mainstream credit-card companies also hold considerable allure for merchants.