This episode explores the nature of the greenhouse effect (discovered by Joseph Fourier and Svante Arrhenius), and the evidence demonstrating the existence of global warming from humanity's influence. Tyson begins by describing the long-term history of the planet Venus; based on readings from the Venera series of probes to the planet, the planet had once had an ocean and an atmosphere, but due to the release of carbon dioxide from volcanic eruptions, the runaway greenhouse effect on Venus caused the surface temperatures to increase and boiled away the oceans. Tyson then notes the delicate nature of the amount of carbon dioxide in the atmosphere can influence Earth's climate due to the greenhouse effect, and that levels of carbon dioxide have been increasing since the start of the 20th century. Evidence has shown this to be from mankind's consumption of oil, coal, and gas instead of from volcanic eruptions due to the isotopic signature of the carbon dioxide. The increase in carbon dioxide has led to an increase in temperatures, in turn leading to positive feedback loops of the melting polar ice caps and dethawing of the permafrost to increase carbon dioxide levels. Tyson then notes that humans have discovered means of harvesting solar power, such as Augustin Mouchot's solar-driven motor in the 19th century, and Frank Shuman's solar-based steam generator in the 1910's. Tyson points out that in both cases, the economics and ease of using cheap coal and oil caused these inventions to be overlooked at the time. Today, solar and wind-power systems would be able to collect enough solar energy from the sun easily. Tyson then compares the motivation for switching to these cleaner forms of energy to the efforts of the Space race and emphasizes that it is not too late for humanity to correct its course.

Tyson describes the discovery of cosmic rays by Victor Hess through high-altitude balloon trips. Swiss Astronomer Fritz Zwicky, in studying supernovae, postulated that these cosmic rays originated from these events instead of electromagnetic radiation. Also tells how Vera Rubin observed that the rotation of stars at the edges of observable galaxies did not follow expected rotational behavior leading to consider the existence of dark matter. This further led to the discovery of dark energy to account for the increasing rate of expansion of the universe. Tyson then describes the interstellar travel of the two Voyager probes. Tyson tells the Carl Sagan's role in the Voyager program, including creating the Voyager Golden Record to encapsulate humanity and Earth's position in the universe. Tyson concludes the series by emphasizing Sagan's message on the human condition in the vastness of the cosmos, and to encourage viewers to continue to explore and discover what else the universe has to offer.

Professor Brian Cox examines how it was that in a universe made of stars, rocks and endless space, a conscious civilisation was born. His latest adventure takes him from a submerged space station in Star City on the outskirts of Moscow, to Ethiopia, high above in the Great Rift Valley, where he encounters the geladas, mankind's distant ancestors. Despite once being Africa's most successful primate, a species who at one time roamed across the entire continent, these days they are found in one just place in the remote Ethiopian Highlands. Cox investigates why these ancestors retreated, yet modern mankind has expanded across the planet.

In episode two, Professor Brian Cox is off to India, where he assesses arguably the first evidence of rational thought in literature, the poetry of the Vedic monks. They pondered mankind's origins, realising there must have been a day with no yesterday - a day of creation - prompting the age-old question of where did the universe come from? Brian marvels that the universe seems to follow a set of rules, the laws of physics, allowing space to be considered on the grandest scale, travelling to the most distant, farthest reaches of the cosmos just by using our minds. Brian also visits Japan, and offers viewers the idea that man lives in just one of an infinite number of universes that are being made all the time.

On a trip to the fortified Moroccan village of Ait-Ben-Haddou in the Atlas Mountains, Professor Brian Cox reveals how by watching the stars' motion across the night sky, it is quite natural for man to think he is at the centre of everything. That view was held for many ages, but innate human curiosity has eventually led to an understanding of mankind's true place in space and time, and an appreciation that Earth is not a focal point but a mere particle of rock in a possibly infinite expanse of space, 13.8 billion years from the beginning of the universe.

Are the wealthy just born in the right place at the right time? Are the poor victims of a system designed to keep them down? Or do physics and biology determine who is rich and who is poor? Throughout history, distribution of wealth is governed by hidden forces: DNA, environmental stress, patterns of human migration and even the laws of thermodynamics! Nature seems to demand winners and losers in life. But does this mean greed is king, and the rich can take what they want? Or is cooperation – between microorganisms, monkeys, and humans – more essential to survival of a species?