Episode 3 delves into how life began on a roiling, violent Earth and explores the story behind Victor Goldschmidt, the man who found the first clues to life's beginnings on our planet. Neil deGrasse Tyson takes viewers on a journey through space and time to witness the tenacity and creativity of life on Earth and the prospects of life throughout the universe.

The fourth episode sees host Neil deGrasse Tyson exploring our eternal quest to end hunger and honoring Nikolai Ivanovic Vavilov, pioneer of modern plant breeding, who risked his life for a discovery that would change the history of science. Vavilov's story is marked by both the tenacity and creativity and is particularly tragic. Interwoven into Vavilov's somber narrative are warnings and treatments of science and its ethical implications, especially when science itself comes under attack from political forces.

In the fifth episode Neil deGrasse Tyson explores questions that have baffled scientists for centuries. Can we know the universe? Are our brains capable of comprehending the cosmos in all of its complexity and splendor?. We don't yet know the answers because our brain remains almost as much of a mystery to that questions as the universe itself. An abandoned orphan's dream opened the way to understanding the architecture of thought.

A child lies on the rug of a tenement dreaming of interstellar adventures. At the dawn of the space age, a young Carl Sagan’s career is forged in the clash of his mentors, two scientific titans. Sagan goes on realize his childhood dreams, to carry their research forward and communicate its significance to the whole world.

Episode 7 focuses specifically on first contact and the search for intelligent life in the vastness of the cosmos. Are humans ready to make first contact with other intelligent beings? Is our technology even sophisticated enough to detect communication signals from another world? Who are we to search for alien intelligence when we can't even recognize or respect the consciousness all around us, or even beneath our feet.
Neil deGrasse Tyson reveals the hidden underground network that is a collaboration of four kingdoms of life, and a true first contact story between humans and beings who communicate in a symbolic language and have maintained a representative democracy for many tens of millions of years.

The 8th episode reviews Giovanni Cassini's life. His observations of Saturn and its moons would have an enduring effect on the scientific world. Neil deGrasse Tyson also narrates the mysterious untold story of the scientist who figured out how to go the Moon while fighting for his life in a WWI trench. Aleksandr Shargei changed his name to Yuri Kondratyuk out of fear for his life and wrote a manuscript on rocket motion and space colonization. This letter would end up capturing the attention of an engineer working on the Apollo program, John Houbolt, and would made the Apollo Mission possible.
We will also know the saga of the twenty-year long odyssey of Cassini-Huygens spacecraft, a robotic explorer ordered to commit suicide on another world.