Just 92 elements made up the world, but the belief that were only four - earth, fire, air and water - persisted until the 19th Century. Professor Al-Khalili retraces the footsteps of the alchemists who first began to question the notion of the elements in their search for the secret of everlasting life.He reveals the red herrings and rivalries which dogged scientific progress, and explores how new approaches to splitting matter brought us both remarkable elements and the new science of chemistry.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Evolution tells us that all life exists for only one purpose: to reproduce. But is that all there is? How could such a simple imperative lead us to create great art and civilizations? A new theory suggests that instead of passing on genes, our ultimate purpose is to process and pass on information. We are the universe figuring itself out. Scientists dig deep into DNA, chemistry, technology and engineering to find the meaning of life. One thing is certain: living is easier if you find a reason for living.

In this episode, Helen seeks out the colours that turned planet Earth multicoloured. To investigate the essence of sunlight Helen travels to California to visit the largest solar telescope in the world. She discovers how the most vivid blue is formed from sulfur atoms deep within the Earth's crust and why the presence of red ochre is a key sign of life. In gold, she discovers why this most precious of metals shouldn't even exist on the surface of the planet and in white, Helen travels to one of the hottest places on Earth to explore the role salt and water played in shaping planet Earth.

In part two, Professor Al-Khalili looks at the 19th century chemists who struggled to impose an order on the apparently random world of the elements. From working out how many there were to discovering their unique relationships with each other, the early scientists' bid to decode the hidden order of the elements was driven by false starts and bitter disputes. But ultimately the quest would lead to one of chemistry's most beautiful intellectual creations - the periodic table.

In the second stop in his exploration of the wonders of the universe, Professor Brian Cox goes in search of humanity's very essence to answer the biggest questions of all: what are we? And where do we come from? This film is the story of matter - the stuff of which we are all made. Brian reveals how our origins are entwined with the life cycle of the stars. But he begins his journey here on Earth. In Nepal, he observes a Hindu cremation. Hindu philosophy is based on an eternal cycle of creation and destruction, where the physical elements of the body are recycled on to the next stage. Brian draws a parallel with the life cycle of the stars that led to our own creation. Next, he explains how the Earth's resources have been recycled through the ages. How every atom that makes up everything we see, was at some time a part of something else. Our world is made up of just 92 elements, and these same 92 elements are found throughout the entire universe. We are part of the universe because we are made of the same stuff as the universe.