Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

This episode explores the palaeogeography of Earth over millions of years, and its impact on the development of life on the planet. Tyson starts by explaining that the lignin-rich trees evolved in the Carboniferous era about 300 million ago, then explains on the nature of plate tectonics that would shape the landmasses of the world and the asteroid impact that initiated the Cretaceous–Paleogene extinction event, leaving small mammals as the dominate species on earth. Earth's landmasses are expected to change in the future and postulates what may be the next great extinction event.

In a late Jurassic forest in what is now China, an Epidexipteryx escapes from a juvenile Sinraptor by climbing a tree. It finds a beetle grub in the tree bark, being shown to use its elongated fingers in a similar way to a modern day aye-aye. However, its prey is stolen by another, larger Epidexipteryx, and after a brief bout of posturing, the smaller individual goes to find more food. It drops a second grub to the forest floor, where the other Epidexipteryx retrieves it, only to be killed by the juvenile Sinraptor. The episode then cuts to a desert in late Cretaceous Mongolia, where a Saurornithoides is shown brooding a nest of eggs. When it leaves the nest, an Oviraptor raids it, fleeing when the troodontid returns. The Saurornithoides is suddenly attacked and eaten by a Gigantoraptor, which then heads to compete in a breeding ritual for mates. The males use their feathers for display, a brief fight between two erupting at one point, allowing the females to choose the best suitor. The episode finally cuts to an early Cretaceous forest in China, where a Xianglong is being hunted by a Microraptor, which uses its feathers to pursue the gliding lizard in the air. A Sinornithosaurus attacks it, and after a brief chase the Microraptor manages a lucky escape. The Sinornithosaurus, alongside two other members of its species is then shown hunting a Jeholosaurus and its three young. The group brings down the parent, the narrator explaining that their possibly venomous bite allowed them to tackle animals much larger than themselves. A montage is then shown of the feathered dinosaurs featured in the programme, with the narrator saying that Microraptor not only hints at how flight might have developed, but also that dinosaurs still live amongst us today, as birds.

In late Cretaceous Canada, in what will be known as Dinosaur Provincial Park, a Daspletosaurus stalks a Chasmosaurus in a forest, but loses the element of surprise and is forced to retreat. The Chasmosaurus comes across a younger Daspletosaurus, before being ambushed by a group of the tyrannosaurids. The episode then cuts to the high Arctic, where Edmontosaurus are hunted by a large species of Troodon. The theropods attack at night, separating a juvenile from the herd and severely wounding it, only to be driven away by an adult. In the morning, they return to eat the carcass of the juvenile, which died during the night. The episode returns to the Daspletosaurus, who chase and bring down the Chasmosaurus. The larger adults bully the youngsters off the carcass, forcing them to wait until they have finished. The episode then cuts to Madagascar, where a mother Majungasaurus (an Abelisaurid) and her two offspring chase a group of Rahonavis off a carcass. However, they are temporarily driven off themselves by a male Majungasaurus. But, after he steals some food from one of the young, the female attacks him, before she and her young cannibalise his body. The episode returns once again to North America, where the Daspletosaurus are waiting for the annual migration of Centrosaurus. They attack during a rainstorm, killing some of the ceratopsians. The Centrosaurus make it to a flooded river and begin to swim across, and although many make it to the other side, some are caught by giant crocodilians or are severely wounded by floating debris and thus drown, or drown for unseen reasons. In the morning, the carcasses attract scavengers, including the Daspletosaurus. A montage is then shown of Daspletosaurus and Majungasaurus, the narrator saying that together, the tyrannosaurids and abelisaurids were the last of the killer dinosaurs.

In the second episode, Dreadnoughtus males compete for the right to mate. Lizards are hunted by Velociraptor among a group of sleeping Tarbosaurus. A Mononykus forages for termites and investigates new food options after a brief rainstorm. Several types of dinosaurs congregate around a watering hole in Mongolia.
Above the deserts of North Africa, aerial combat ensues as male Barbaridactylus pterosaurs fight for the attention of females below. A herd of Secernosaurus brave the harsh gypsum dunes in search of nourishment.

In the third episode, a Velociraptor hunts pterosaurs on a cliffside by a waterfall. A battle-scarred Tyrannosaurus nurses his wounds and encounters a newcomer. With its feathered body and duck bill, the eight-ton Deinocheirus wades through an Asian wetland in search of relief from pesky biting flies.
A female Quetzalcoatlus builds and guards her nest. A mother Masiakasaurus and her family hunt crabs. Elasmosaurs enter an estuary in search of fish.