Tony Accardo have taken the reins of the criminal empire built by their mentor Al Capone. Thanks to Sam Giancana's takeover of the policy racket, the gangsters are now making millions. With so much money coming in, Accardo knows they need a place to hide it. They find their answer in a growing city where gambling is now legal: Las Vegas. However, the New York mafia is already there, led by criminal mastermind Meyer Lansky.

Rejected by Vorenus and Eirene and racked by guilt for the killing of Eirene's fiancé out of a jealous rage, Pullo has sunk to working as an assassin for the gangster Erastes. When Pullo gets arrested for killing one of Caesar's popular opponents, he condemns himself by refusing to name who hired him, despite Octavian's attempts to defend him.
Meanwhile, Vorenus finds his new official duties as magistrate tedious, especially when he gets caught between Caesar and the demands made by veterans' spokesman Mascias.

Even though his wife and children are avenged by the Erastes killing, Lucius Vorenus keeps mourning for over a month till Pullo gets Marc Antony who scolds him for Caesar's death and the continuing bloody Aventine gang riots that have resulted in the gangs wanting to fill the void left by Erastes sudden demise.
Octavian is loosing patience with Mark Antony for payment of Caesar's inheritance. Meanwhile, Queen Cleopatra of Egypt arrives in Rome to pay her respects to Caesar and she also negotiates with Antony's military protection for her Pharaonic throne.

The last installment of the series features a revealing first-person account that delves into the complexities of Gotti's mentorship and the stark realities of gang life. From a determined youth facing rejection from his father to his bold declaration to work for Gotti, witness the tumultuous ascent of Sammy ‘The Bull’ Gravano within the criminal underworld.
The narrative captures a pivotal confrontation, where Gotti chillingly outlines the dark path ahead, juxtaposed against the awe-inspiring backdrop of the Justice Department in Washington D.C., a symbol of the relentless pursuit that future gangsters will inevitably face. This episode doesn’t just recount events; it places you at the heart of an ongoing battle against organized crime, providing an intimate look at Gotti’s life, from his rise to power to his ultimate indictment and the intense legal battles that followed. Dive into a gripping exploration of loyalty, power, and the consequences of a life in the mafia.