For one night only, Professor Brian Cox goes unplugged in a specially recorded programme from the lecture theatre of the Royal Institution of Great Britain. In his own inimitable style, Brian takes an audience of famous faces, scientists and members of the public on a journey through some of the most challenging concepts in physics. With the help of Jonathan Ross, Simon Pegg, Sarah Millican and James May, Brian shows how diamonds - the hardest material in nature - are made up of nothingness; how things can be in an infinite number of places at once; why everything we see or touch in the universe exists; and how a diamond in the heart of London is in communication with the largest diamond in the cosmos.

Comedian Ben Miller returns to his roots as a physicist to try to answer a deceptively simple question: what is one degree of temperature? His quest takes him to the frontiers of current science as he meets researchers working on the hottest and coldest temperatures in the universe, and to a lab where he experiences some of the strangest effects of quantum physics - a place where super-cooled liquids simply pass through solid glass. Plus, Ben installs his very own Met office weather station at home. Ben's investigations in this personal and passionate film highlight the importance of measurement and accuracy in the 21st century.

The key to understanding the universe seems to be understanding its smallest components. But the quantum realm bears little resemblance to the universe we know. Image a particle that can be many places at the same time and communicate changes instantly across vast distances, even to the other side of the Universe. Shrinking down billions of times, into the realm of atoms and sub-atomic particles, takes us into a bizarre world of paradoxes and multiverses. Explore with us quantum physics and the potential applications in computer science.

We move around in space, but we are stuck in a prison of time moving ever forwards. Einstein said, 'The distinction between past, present and future is only a stubbornly persistent illusion.' Is our experience of the ticking clock merely a trick of the mind? Could science ever make the clock move backwards? Experiments in quantum physics are showing that the future influences the present: what happens later limits the choices we think we have now. The laws of physics say visiting or talking to ourselves in the past is possible – but changing history once we get there is not.

In this episode, Michael demonstrates how our society is built on our search to find the answer to what makes up everything in the material world. This is a story that moves from the secret labs of the alchemists and their search for gold by the stone of the philosophers to the creation of the world's first synthetic dye - Purple - and onto the invention of the transistor. This quest may seem abstract and highly theoretical. Yet it has delivered the greatest impact on humanity. By trying to answer this question, scientists have created theories from elements to atoms, and the strange concepts of quantum physics that underpin our modern, technological world.

Our world, our solar system, our universe, none of it would exist without a ghostly particle called the neutrino. They are our early warning system whenever there's trouble in the universe. Neutrinos trigger star-killing explosions, supernovas. Neutrinos can answer so many questions, from why do we exist to how was the universe created. Neutrinos can be the very reason that we exist at all. The more we understand these elusive particles, the more we can gain insight into how the universe works.