Andrew Graham-Dixon begins his exploration of German art by looking at the rich and often neglected art of the German middle ages and Renaissance. He visits the towering cathedral of Cologne, a place which encapsulates the varied and often contradictory character of German art. In Munch he gets to grips with the earliest paintings of the Northern Renaissance, the woodcuts of Albrecht Durer and the cosmic visions of the painter Albrecht Altdorfer. Andrew also embarks on a tour of the Bavarian countryside, discovering some of the little-known treasures of German limewood sculpture.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

Andrew Graham-Dixon reveals how the Medici family transformed Florence through sculpture, painting and architecture and created a world where masterpieces fetch millions today. Without the money and patronage of the Medici we might never have heard of artists such as Donatello, Michelangelo or Botticelli, and Graham-Dixon examines how a family of shadowy, corrupt businessmen, driven by greed and ambition, became the financial engine behind the Italian Renaissance.

Andrew Graham-Dixon examines early Christian art and the reasons for its evolution during the Renaissance. He also reveals just how far modern artists have been influenced by the pre-perspective view of the world.

The story of how the secret of life has been examined through the prism of the most complex organism known - the human body. It begins with attempts to save the lives of gladiators in Ancient Rome, unfolds with the macabre work and near-perfect drawings of Leonardo in the Renaissance, through the idea of the 'life force' of electricity, to the microscopic world of the cell. It reveals how a moral crisis unleashed by work on the nuclear bomb helped trigger a great breakthrough in biology - understanding the structure and workings of DNA.

On a spectacular journey through Renaissance Italy, Andrew Graham-Dixon searches for the shadowy figure who wrote one of the most important books on art and looks at some dazzling works, including masterpieces of the early Renaissance by Giotto, Masaccio and Donatello. Giorgio Vasari was the grandaddy of all art critics, travelling Italy in the 16th century for his definitive Lives of the Artists. It was a time of miracles that he named 'the Renaissance'.