This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

During a Gurkha recruitment Palin is disturbed by Maoist insurgents, but survives to suffer as he climbs to 15,000 feet and sees the majesty of Annapurna Sanctuary. In Kathmandu he is blessed by the Nepalese king before meeting some holy men. Crossing into Tibet, he meets his first yaks at the highest monastery in the world, before heading up the Rongbuk glacier towards the summit of Everest.

In Bhutan, Palin finds himself back in the land of yaks for a last look at the high Himalaya. Trekking to Chomolhari base camp he meets a nomad with a penchant for yak songs before heading down to Paro to witness the Buddhist festival or Tsechu. In a bar in Thimphu, he discusses reincarnation and the pursuit of happiness with Benji and Khendum, two of the king's cousins, and en route to Bangladesh is taken by Benji to see the rare black-neck cranes. On his journey south through Bangladesh, Michael visits the ship-breaking beaches of Chittagong and grid-locked Dhaka. He meets a man who made a fortune in Birmingham in the poultry business, and a woman who lends money only to women. On a 1920s paddle steamer he is serenaded with the words of Bengal's Shakespeare, and he completes his epic Himalayan journey aboard a fishing boat that carries him out into the Bay of Bengal and a westering sun.

Even after thousands of years of ice crushing the northern hemisphere and temperatures of 20 degrees lower than those of today, many of the great giants of the ice age still walked the earth. It was only when the world had warmed up again that mammoths, woolly rhinos, sabre-toothed cats, giant ground sloths and glyptodonts finally became extinct. Professor Alice Roberts sets off on her last voyage back to the Ice Age to discover why.

Our icy adventure begins with host Dr. Iain Stewart in the Alps, where he goes down an ice crevasse to show viewers how snowfall develops into expansive masses. Then, we see how ice can shape the earth's topography giving rise to features like Yosemite National Park and Manhattan Island, in NY. Finally, journey to Greenland and see how ice sheets and glaciers are melting at a phenomenal rate that is likely to accelerate over the coming years, changing the world as we know it.

Tyson describes the discovery of cosmic rays by Victor Hess through high-altitude balloon trips. Swiss Astronomer Fritz Zwicky, in studying supernovae, postulated that these cosmic rays originated from these events instead of electromagnetic radiation. Also tells how Vera Rubin observed that the rotation of stars at the edges of observable galaxies did not follow expected rotational behavior leading to consider the existence of dark matter. This further led to the discovery of dark energy to account for the increasing rate of expansion of the universe. Tyson then describes the interstellar travel of the two Voyager probes. Tyson tells the Carl Sagan's role in the Voyager program, including creating the Voyager Golden Record to encapsulate humanity and Earth's position in the universe. Tyson concludes the series by emphasizing Sagan's message on the human condition in the vastness of the cosmos, and to encourage viewers to continue to explore and discover what else the universe has to offer.