Sultan Mehmed II's siege of Constantinople enters its third week. Mehmed's artillery teams continue their relentless bombardment of Constantinople's walls. After his navy suffers a devastating defeat, Mehmed moves his ships overland to the Golden Horn in a daring, visionary feat. In the shadow of betrayal, Giustiniani attacks the Ottoman fleet.

Autistic minds provide windows into how we all think, feel, and behave. A complete brain science should be able to account for all kinds of minds and brains. As long as some minds remain a mystery, so too will all minds.
Michael Stevens travels to London to meet a blind, autistic savant with astonishing musical abilities, and volunteers to have his brain's function temporarily disrupted at UCLA's Neuromodulation Lab.

The fourth episode sees host Neil deGrasse Tyson exploring our eternal quest to end hunger and honoring Nikolai Ivanovic Vavilov, pioneer of modern plant breeding, who risked his life for a discovery that would change the history of science. Vavilov's story is marked by both the tenacity and creativity and is particularly tragic. Interwoven into Vavilov's somber narrative are warnings and treatments of science and its ethical implications, especially when science itself comes under attack from political forces.

We inhabit a cosmos of undiscovered dimensions and paradoxical realities. We live on one level of perception, but there are others. Every once in a while, a searcher happens upon the doorway to one of these other levels. One of them discovered a paradox about reality that proved to be so profound, we have yet to understand how it could be possible. The universe, or perhaps we should say, universes have never been the same.
In the counterintuitive realm of quantum mechanics, light can be two contradictory things, and somehow - no one knows how - an unseen observer can alter the nature of reality. The man who stumbled on this hole in reality and the still- unfolding technological revolution that it made possible.

Inside the heart of the atom, its nucleus houses energy. This hidden treasure was forged billions of years ago in distant stellar furnaces. The secret of starlight is nothing to fool with. It can bring a civilization to life and it can burn it to the ground.
Two atoms from different parts of the universe meet on a small planet. A deadly embrace between science and state altered the fate of the world and a gripping cautionary tale of others who grew used to living in the shadow of grave danger until it killed them all except one.

At 11 o'clock on New Year's Eve of the Cosmic Calendar, Homo erectus stood up for the first time, freeing its hands and earning the species its name. They began to move around, to explore, daring to risk everything to get to unknown places. Our Neanderthal relatives lived much as we did and did many of the things we consider to be 'human.' More restless than their cousins the Neanderthals and Denisovans, our Homo sapiens ancestors crossed seas and unforgiving landscapes, changing the land, ocean and atmosphere, leading to mass extinction. The scientific community gave our age a new name, 'Anthropocene.'
Since the first civilizations we've wondered if there's something about human nature that contains the seeds of our destruction. Syukuro Manabe was born in rural Japan and took an intense interest in Earth's average global temperature. In the 1960's, he would assemble the evidence he needed to predict the increase of Earth's temperature due to greenhouse gases until it becomes an uninhabitable and toxic environment, leading to our extinction. 'This doesn't have to be,' says Neil deGrasse Tyson, 'it's not too late. There's another hallway, another future we can still have; we'll find a way.'