Horizon investigates the idea that the best way to lose weight successfully is a personalised approach, diets tailored to our individual biology and psychology. In a groundbreaking experiment, Dr Chris van Tulleken and Tanya Byron join a team of experts to put 75 overweight volunteers on diets designed to tackle the specific reasons why they eat too much. The volunteers are put through a series of tests at a residential clinic to understand how their genes, hormones and psychology influence their eating behaviour. They are then put on the diets the experts believe are best suited to them. Can science succeed where other diets have failed?

In the dark depths of the oceans, nearly 90% of all species light up the darkness from within. These creatures flash, sparkle, shimmer, or simply glow. Whether it’s to scare off predators, fish for prey, or lure a mate, the language of light is everywhere in the ocean depths, and scientists are finally starting to decode it. Discover surprising ways to harness nature’s light—from tracking cancer cells to detecting pollution, lighting up cities, and even illuminating the inner workings of our brains.

Memory is the glue that binds our mental lives. Without it, we’d be prisoners of the present, unable to use the lessons of the past to change our future. From our first kiss to where we put our keys, memory represents who we are and how we learn and navigate the world. But how does it work? Neuroscientists using cutting-edge techniques are exploring the precise molecular mechanisms of memory". By studying a range of individuals ranging —from an 11-year-old whiz-kid who remembers every detail of his life to a woman who had memories implanted— scientists have uncovered a provocative idea. For much of human history, memory has been seen as a tape recorder that faithfully registers information and replays intact. But now, researchers are discovering that memory is far more malleable, always being written and rewritten, not just by us but by others. We are discovering the precise mechanisms that can explain and even control our memories. The question is— are we ready?

Dr Michael Mosley and Professor Alice Roberts investigate if male and female brains really are wired differently. New research suggests that the connections in men and women's brains follow different patterns, patterns which may explain typical forms of male and female behaviour. But are these patterns innate, or are they shaped by the world around us?" Using a team of human lab rats and a troop of barbary monkeys, Michael and Alice test the science and challenge old stereotypes. They ask whether this new scientific research will benefit both men and women - or whether it could drive the sexes even further apart.

Of all the wonders of the human body, there's one more mysterious than any other. Blood: five precious litres that keep us alive. Yet how much do we really know about this sticky red substance and its mysterious, life-giving force? Michael Mosley gives up a fifth of his own blood to perform six bold experiments". From starving it of oxygen to injecting it with snake venom, Michael reveals the extraordinary abilities of blood to adapt and keep us alive. Using specialist photography, the programme reveals the beauty in a single drop. Michael even discovers how it tastes when, in a television first, he prepares a black pudding with his own blood. Down the ages, our understanding of blood has been as much myth as science, but Michael reveals there might be truth in the old vampire legends, as he meets one of the scientists behind the latest research that shows young blood might be able to reverse the ageing process - the holy grail of modern medicine.

The video game industry is a global phenomenon. There are over 1.2 billion gamers across the planet, with sales projected soon to pass $100 billion per year. But their very popularity fuels the controversy that surrounds them. They frequently stand accused of corrupting the young - of causing violence and addiction. But is this true? The scientific community is deeply divided". Some are convinced that video games incite aggression. Others insist they have no effect whatsoever on real-world violence. But away from the controversy, there is a growing body of evidence that suggests video games may help keep the brain sharp, and could soon revolutionise how we combat mental decline as we age.