Michael crosses Iran towards the Caspian Sea. He meets nomads who tell of Alexander's tryst with an Amazon queen, and the living descendants of Alexander's Persian enemies, who have their own tales of `Alexander the Accursed'.

Wood travels through war-torn Afghanistan, crossing the Oxus River into Central Asia and the Silk Road city of Samarkand where, in a drunken brawl, Alexander killed the friend who had previously saved his life.

The final leg takes him from the Khyber Pass through Pakistan to the Punjab, where Alexander's army mutinied and he was forced to return across the Makran Desert to Babylon, where he died at only 32 years of age.

This episodes the nature of the cosmos on the micro and atomic scales, using the Ship of the Imagination to explore these realms. Tyson describes some of the micro-organism that live within a dew drop, demonstrating parameciums and tardigrades. He proceeds to discuss how plants use photosynthesis via their chloroplasts to convert sunlight into chemical reactions that convert carbon dioxide and water into oxygen and energy-rich sugars. Tyson then discusses the nature of molecules and atoms and how they relate to the evolution of species. He uses the example set forth by Charles Darwin postulating the existence of the long-tongued Morgan's sphinx moth based on the nature of the comet orchid with pollen far within the flower. He further demonstrates that scents from flowers are used to trigger olfactory centers in the brain, stimulating the mind to threats as to aid in the survival of the species. Tyson narrates how Greek philosophers Thales and Democritus postulated that all matter was made up of combinations of atoms in a large number of configurations, and describes how carbon forms the basic building block for life on earth due to its unique chemical nature. Tyson explains on the basic atomic structure of protons, neutrons, and electrons, and the nature of nuclear fusion that occurs in most stars. He then discusses the existence of neutrinos that are created by these nuclear processes in stars, and that detecting such sub-atomic particles which normally pass through matter require subterranean facilities like the Super-Kamiokande that were used to detect neutrinos from the supernova SN 1987A in the Large Magellanic Cloud before light from the explosion were observed due to their ability to pass through matter of the dying sun. Tyson compares how neutrinos were postulated by Wolfgang Pauli to account for the conservation of energy from nuclear reactions in the same manner as Darwin's postulate on the long-tongued moth. Tyson concludes by noting that there are neutrinos from the Big Bang still existing in the universe but due to the nature of light, there is a "wall of infinity" that cannot be observed beyond.

The constellation of the Pleiades provides a vehicle for us to explore a series of paradoxes and epochal discoveries for humanity. The untold story of the modern "sisters of the sun," the early 20th century female astronomers, led by two deaf women, at Harvard who catalogued the stars. It's also the story of the young British woman who joined forces with them, her defiance of the world's leading expert, and how she taught the world what the stars are really made of.

The German army launched Operation Barbarossa, the invasion of the East, with supreme confidence in its own superiority. High Command was sure that victory would come as quickly and as easily as in France. At the onset, the troops advanced rapidly and the Panzer forces under General Guderian were unbeatable. There were, however, far more casualties and more wear-and-tear on equipment than anticipated. The invading force got bogged down short of Moscow and the withdrawal from there was a severe psychological blow to the men. When an extremely severe winter set in, morale sank further. The soldiers were not equipped for such low temperatures and their guns and machinery could not cope. Hitler ordered his troops to stand firm.