Does life exist on other planets? Astrobiology is a visionary new science that searches for life in space by combining the disciplines of astronomy, biology and geology. How did life evolve on Earth? What will life look like on other planets? These and other pertinent questions will be answered by a diverse group of scientists. Viewers will visit the Pilbara region of West Australia where the oldest evidence of life on Earth has been discovered. Travel to the moons of Jupiter and Saturn to test a theory that life could exist in the clouds of Venus. Finally, watch as experiments are done to see if life exists on exoplanets, earth-like planets beyond our solar system.

Imagine a tornado so powerful, it can form a planet, or winds sweeping across a planet but blowing at 6,000 miles per hour! How about rain....made of iron? Sounds like science fiction, but this type of weather is occurring daily in our solar system. Scientists are just beginning to unlock the secrets of these planets and their atmospheres. Can this research help scientists solve long unanswered questions that we have about Earth? As our own planet churns with the effects of global warming, it's natural to look into the heavens and wonder about the rest of the real estate.

We can't compare anything on earth to the biggest things known in space. The Cosmic Web may connect objects in the universe with threads of Dark Matter. The Lyman-alpha blob is a bubble like structure containing countless galaxies--perhaps the biggest object in the entire universe. Regions of radio-emitting gas called "radio lobes" could be even bigger. Then there are super galaxy clusters which are hundreds of galaxies merged together due to cosmic collisions. Discover which is the largest planet, star, star cluster, constellation, black hole, volcano, galaxy, explosions, moon, storm, impact crater and "void" in space.

Beginning with the separation of the fuzzy thinking and pious fraud of astrology from the careful observations of astronomy, Sagan follows the development of astronomical observation. Beginning with constellations and ceremonial calendars (such as those of the Anasazi), the story moves to the debate between Earth and Sun-centered models: Ptolemy and the geocentric worldview, Copernicus' theory, the data-gathering of Tycho Brahe, and the achievements of Johannes Kepler (Kepler's laws of planetary motion and the first science-fiction novel).

Sagan discusses comets and asteroids as planetary impactors, giving recent examples of the Tunguska event and a lunar impact described by Canterbury monks in 1178. It moves to a description of the environment of Venus, from the previous fantastic theories of people such as Immanuel Velikovsky to the information gained by the Venera landers and its implications for Earth's greenhouse effect. The Cosmos Update highlights the connection to global warming.

The journeys of the Voyager probes is put in the context of the Netherlands in the seventeenth century, with a centuries-long tradition of sailing ship explorers, and its contemporary thinkers (such as Constantijn Huygens and his son Christian). Their discoveries are compared to the Voyager probes' discoveries among the Jovian and Saturn systems. In Cosmos Update, image processing reconstructs Voyager’s worlds and Voyager’s last portrait of the Solar System as it leaves is shown.