Richard Dawkins explores what science can tell us about death. It's a journey that takes him from Hindu funeral pyres in India to genetics labs in New York.Dawkins brings together the latest neuroscience, evolutionary and genetic theory to examine why we crave life after death, why we evolved to age and how the human genome is something like real immortality - traits inherited from our distant ancestors that we pass on to future generations.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Evolution tells us that all life exists for only one purpose: to reproduce. But is that all there is? How could such a simple imperative lead us to create great art and civilizations? A new theory suggests that instead of passing on genes, our ultimate purpose is to process and pass on information. We are the universe figuring itself out. Scientists dig deep into DNA, chemistry, technology and engineering to find the meaning of life. One thing is certain: living is easier if you find a reason for living.

Sagan reflects on the future of humanity and the question of 'who speaks for Earth?' when meeting extraterrestrials. He discusses the very different meetings of the Tlingit people and explorer Jean-François de La Perouse with the destruction of the Aztecs by Spanish conquistadors, the looming threat of nuclear warfare, and the threats shown by destruction of the Library of Alexandria and the murder of Hypatia. The episode ends with an overview of the beginning of the universe, the evolution of life, and the accomplishments of humanity and makes a plea to mankind to cherish life and continue its journey in the cosmos. The Cosmos Update notes the preliminary reconnaissance of planets with spacecraft, the fall of the Berlin Wall and the end of apartheid in South Africa, and measures towards the reduction of nuclear weapons.

Iain explores man's relationship with fire. He begins by embarking on an extraordinary encounter with this terrifying force of nature - a walk right through the heart of a raging fire. Fire has long been our main source of energy and Iain shows how this meant that the planet played a crucial role in Britain's industrial revolution, whilst holding China's development back. Along the way he dives in a mysterious lake in Oregon, climbs a glacier of salt, crawls through an extraordinary cave in Iran and takes a therapeutic bath in crude oil.

'Blood Brothers' follows the lives of two species, Paranthropus boisei and Homo habilis who embody two alternative ways of ape-man life. Although heavyset, with distinctive gorilla-like faces, the boisei are gentle characters. They live within a strict social structure and are led by a dominant male whose strength and power holds the group together. The habilis have taken a different approach to survival. They don't have the specialisms of the boisei but instead have developed into the archetypal jack-of-all-trades, inquisitive scavengers prepared to try almost anything to survive. Tough, active, gregarious and noisy, they are always on the move and always alert to the possibility of a meal. But in the near drought of the dry season the habilis are struggling. It seems as if their way of life cannot help them when conditions are tough.