Hernan Cortes left Cuba in 1519 seeking riches in the island to the west. Instead he discovered, and ultimately destroyed, a hitherto unknown civilization. Join Micheal Wood as he retraces this fateful expedition. Read Spanish eyewitness accounts that describe the conquistadors' awe at the Aztec achievements and the lust for native treasure. Learn the Aztec' side of the story by scrolling trough pictographs that tell of the agonizing fall of the empire.

Richard Dawkins examines the growing suspicion the public has for science-based medicine, despite its track record of successes like the germ theory of disease, vaccines, antibiotics and increased lifespan. He notes a fifth of British children are currently not immunised against measles, mumps and rubella, attributing it to fears arising from a highly controversial report linking the vaccine with autism. Dawkins criticizes the growing field of alternative medicine which does not pass the same objective and statistical rigour as scientifically derived treatments using controlled double-blind studies. Without verifiable evidence, alternative therapies must rely on biased anecdotes and word of mouth to perpetuate. Dawkins observes these treatments have fanciful rationales and rituals behind them, with many alternative treatments employing pseudoscientific jargon such as "energy", "vibration" or "quantum theory" to give themselves greater credence to patients.

In 1962 Hitchcock and Truffaut locked themselves away in Hollywood for a week to excavate the secrets behind the mise-en-scène in cinema. Based on the original recordings of this meeting-used to produce the mythical book Hitchcock/Truffaut-this film illustrates the greatest cinema lesson of all time and plummets us into the world of the creator of Psycho, The Birds, and Vertigo. Hitchcock's incredibly modern art is elucidated and explained by today's leading filmmakers: Martin Scorsese, David Fincher, Arnaud Desplechin, Kiyoshi Kurosawa, Wes Anderson, James Gray, Olivier Assayas, Richard Linklater, Peter Bogdanovich and Paul Schrader.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

In 1927, Prohibition agent Eliot Ness narrowly escapes a hit ordered by Al Capone. Determined to prove to Capone that he's not intimidated, Ness and his team of Untouchables execute a series of high-profile raids on Capone's breweries. Over the course of a few months, they destroy more than 200,000 gallons of beer, worth a modern-day equivalent of $134 million - and the newspapers cover it all. Capone lashes out against Ness in the press. What Capone doesn't realize is that Ness and the Prohibition agents aren't the only ones trying to take him down. For the past four years, another government agency with more manpower and resources than Ness has been going after the infamous kingpin: the Internal Revenue Service.

The rise of alternative rock in the USA. From its early underground days where bands like Black Flag drew inspiration from the DIY ethos of punk. We explore why the bands that emerged from the underground offered an alternative both to the established music industry and the prevailing politics. Bands like R.E.M., The Pixies and Husker Du, REM breaking into the mainstream charts with 'Losing My Religion', Seattle 'grunge' scene, culminating in the success of Nirvana's 'Nevermind'