Hanging in the Barnes Foundation in Philadelphia, Seurat’s Les Poseuses is probably his least-known painting. It is also a picture brimming with codes and hidden meanings. It shows three nudes in the artist’s studio, but included in the background is Seurat’s famous masterpiece, A Sunday Afternoon on the Island of La Grande Jatte. Why is it there? What is it trying to say? Why two pictures at once? Waldemar Januszczak investigates.

At 11 o'clock on New Year's Eve of the Cosmic Calendar, Homo erectus stood up for the first time, freeing its hands and earning the species its name. They began to move around, to explore, daring to risk everything to get to unknown places. Our Neanderthal relatives lived much as we did and did many of the things we consider to be 'human.' More restless than their cousins the Neanderthals and Denisovans, our Homo sapiens ancestors crossed seas and unforgiving landscapes, changing the land, ocean and atmosphere, leading to mass extinction. The scientific community gave our age a new name, 'Anthropocene.'
Since the first civilizations we've wondered if there's something about human nature that contains the seeds of our destruction. Syukuro Manabe was born in rural Japan and took an intense interest in Earth's average global temperature. In the 1960's, he would assemble the evidence he needed to predict the increase of Earth's temperature due to greenhouse gases until it becomes an uninhabitable and toxic environment, leading to our extinction. 'This doesn't have to be,' says Neil deGrasse Tyson, 'it's not too late. There's another hallway, another future we can still have; we'll find a way.'

The Vision After the Sermon, also known as Jacob Wrestling with the Angel, is a painting full of symbolism and mystery. But what does Gauguin’s famous work have to do with a 17-year-old girl called Madeleine, with Victor Hugo’s Les Miserables, and with sumo wrestlers?
Waldemar Januszczak reveals all as he investigates Gauguin’s epic religious painting about good and evil, temptation and desire.

Details one of the most elaborately staged theatrical productions in music history as Pink Floyd frontman Roger Waters performs the band's critically acclaimed album The Wall in its entirety.
The tour 'Roger Waters: The Wall' were performed from September 2010 to September 2013. The film have lots of footage from the concerts and other materials that have been filmed recently by Roger Waters – like his visit to his father’s grave in Italy that featured a film crew.

In the second part and conclusion, a spotlight on the mass marketing of the synthetic opioid fentanyl examines the connections between drug manufacturers and government policy. Video of sales retreats and promotional material reveals a deep cynicism among company employees and a disregard for the widespread, nefarious corporate practices.

Dr Chris van Tulleken, Dr Hannah Fry and Michael Mosley examine the latest research and explore some of the big questions about Covid-19 and the pandemic it has created. Michael visits the UK government's high-security laboratory Porton Down, where vaccines are being tested. He also uncovers what the experience of the 2002 SARs epidemic reveals about this one. Both were caused by coronaviruses, but certain key changes to today's virus have allowed it to infect the world, where SARs was contained.