Series concludes with the focus shifting to the United States in the post-war years of the 1950s and beyond. Beginning with arguably the most notorious work of 20th century classical music, John Cage's 'silent' composition 4'33", it looks at how a series of maverick Americans re-invented the sound of classical music into a more simple form, bringing back harmonies and rhythms that made it increasingly popular with audiences across the world. It also examines how this music found its way into a spiritual realm, with the strain of pared-down religious composition that came to be known as 'holy minimalism'. From the Maverick concert hall in Woodstock, New York to an Orthodox cathedral in Estonia to a car park in Peckham, south London, the story is told by a stellar line-up of contributors including Philip Glass, Steve Reich, John Adams, Arvo Pärt and John Tavener.

The tour was designed by Willie Williams, who has worked on every U2 tour since 1982. Williams had been toying with ideas for 360-degree stadium staging for U2 for a number of years, and presented sketches of a four-legged design to the group near the end of their Vertigo Tour in 2006. The inspiration for the 'spaceship-on-four-legs' design, nicknamed 'the Claw', came from the landmark Theme Building at Los Angeles International Airport.

The 25 October 2009 concert in Pasadena, California was streamed live on U2's YouTube channel, the first time a concert was streamed live on YouTube. Over 10 million viewers streamed the concert, making it the largest streaming event in the website's history. The shoot was directed by Tom Krueger, who had previously worked with the band on the film U2 3D.

Atheist and scientist Richard Dawkins visits England, America and Israel interveiwing prominant people of faith; Islamic, Hasidic Jews, and the new Christian sects popping up throughout the world, and expressing his view of the extent to which this fanaticism has degraded our civilisation, and will continue to degrade it. "The God Delusion" explores the unproven beliefs that are treated as factual by many religions and the extremes to which some followers have taken them. Dawkins opens the programme by describing the "would-be murderers ... who want to kill you and me, and themselves, because they're motivated by what they think is the highest ideal." Dawkins argues that "the process of non-thinking called faith" is not a way of understanding the world, but instead stands in fundamental opposition to modern science and the scientific method, and is divisive and dangerous.

Nathan and Angela accelerate their parenting rehearsal with three-year-old, then six-year-old actors portraying their fake son, 'Adam'. Angela refuses to participate in Halloween due to her belief in Satanic conspiracies.
Nathan balances parenting duties with a rehearsal for Patrick, a man who wants to confront his brother over their late grandfather's will, which bans Patrick from inheriting money if he is dating a 'gold digger'. The rehearsal occurs in a replica Raising Cane's restaurant in a warehouse next to the relocated Alligator Lounge. To introduce real emotions to the rehearsal, Nathan stages a scenario to convince Patrick that he could inherit buried gold from the grandfather of Isaac, the actor who plays Patrick's brother. After Patrick has an emotional breakthrough during a rehearsal, he leaves the production and never returns. Nathan narrates that he is envious that self-deception is easy for some people as he ponders his fake family.

Dr Adam Rutherford shows how decoding the genome has led us to begin to understand the very process by which our DNA makes us different; how it makes each one of us on earth unique and influences who we are and the traits we have. He reveals how, as we try and understand the relationship between who we are and our genes, we stand at the beginning of the most exciting scientific journey of all time.