We used to think that Earth was at the centre of the universe, but now we know we're not even at the centre of our own galaxy. Countless wonders exist between where earth is situated and the massive black hole at the galactic centre of our galaxy. Within the Milky Way can be found the debris of old, dying stars fuelling the birth of new stars and at the galactic centre hypervelocity stars get catapulted clear beyond the Milky Way's outer rim at unimaginable speeds. Come along for a guided tour of 100,000 light-year-wide family of stars and stellar phenomena we call The Milky Way.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

Exoplanets, strange worlds outside our solar system. We're discovering the cosmos is full of alien planets. Alien worlds that challenge our understanding of planetary systems. Hellishly hot worlds, violently colliding worlds, worlds getting eaten by their stars. There's much, much more out there than we had ever imagined.
Exoplanets are shaking up our understanding of the universe. The cosmos is a chaotic array of the odd, the weird, and the wonderful. The more we find, the less we know.

The center of our galaxy is one of the most nightmarish places in the cosmos. It's the home to some of the most incredible forces the universe has to offer. Gas streaming everywhere, stars are being born and dying and exploding, radiation blasting out. And at the very heart is the super massive black hole, 4 million times the mass of the sun. But also the Milky Way, is our safe harbour, our island in this vast, cosmic ocean. And so to understand the heart of our galaxy, is to understand our home in this cosmic void.

We're unlocking the secrets of our planet's voyage and discovering that earth's journey affects us all. The Earth is extremely dynamic. It is spinning on its axis, it's whirling about the sun and it's corkscrewing throughout the this galaxy. And there is the fact than Andromeda and the Milky Way are currently 2.5 million light-years apart, but they're hurtling towards each other at over 250,000 miles an hour. A collision is inevitable. As stars, dust, and gas swirl around each other, gravitational interactions could slingshot our solar system out into intergalactic space.