Dave Grohl discusses New Orleans' unique music history with Dr. John, Allen Toussaint and Cyril Neville. The band records in Preservation Hall and also performs with the Preservation Hall Jazz Band. The song 'In the Clear' is recorded during this episode.

The fourth episode starts off with the two riding through Santa Cruz, Argentina. The plan is to cross over into Chile and then going up into the Andes. Ewan and Charley head through Argentina’s red rock landscape while a member of their team copes with altitude sickness. The duo are well and truly underway and the first signs of all are well is how well the Harleys hold up in challenging conditions. The roads alternate between unforgiving and pleasant and these e-bikes push through effortlessly. As they ride through Chilean Andes, the audience is shown a picturesque view of the beauty of the countryside, an experience which Boorman calls 'magical.'

As the journey continues, there's beauty and danger in equal measure for Charley Boorman and Ewan McGrego. The duo ride their electric Harleys through the exotic and breathtaking Bolivian countryside in a tough ascent. The sixth episode showcases some of the challenges the hosts and the crew face when they scale the terrain. One of the Rivians runs into trouble while sandy roads and a heavy breeze sees Boorman take a tumble. Apart from all the accidents, the chapter also shows some quality work done by UNICEF when it comes to educating and working with the children in Bolivia.
The altitude sickness hits Taylor, their logistics man real bad and McGregor starts feeling it as well. The episode ends with a doctor heading to his hotel room to check up on him.

Across the world, rising demands for food, water and materials have pushed resources to the limit. Many parts of the world have major challenges over fresh water. A lot of soils have a lot of residual pesticides and herbicides. At the same time waste is piling higher. All this demands a new wave of innovation. The challenge is to make more of the things we need without the environmental cost.

As the journey continues, there's beauty and danger in equal measure. Charley and Ewan travel through the extraordinary Bolivian desert, but the sandy roads make all more difficult. The duo ride their electric bikes through the exotic and breathtaking countryside and all the way making a challenging ascent. The riders stay in a hotel made entirely out of salt before heading to La Paz. 'Bolivia' also shows some quality work done by UNICEF when it comes to educating and working with the children. McGregor and Boorman spend time with the kids before resuming their journey and ending with a ferry ride over lake Titicaca.

It is the greatest technological challenge ever undertaken by humankind. The quest to produce the ultimate energy solution, Fusion, a reliable source of clean power. What if we could create here on earth, our very own version of a star, a machine that makes power from nuclear fuel? But so immense are the challenges, the goal of a power-producing fusion reactor has so far remained elusive and out of reach... until now.