Autistic minds provide windows into how we all think, feel, and behave. A complete brain science should be able to account for all kinds of minds and brains. As long as some minds remain a mystery, so too will all minds.
Michael Stevens travels to London to meet a blind, autistic savant with astonishing musical abilities, and volunteers to have his brain's function temporarily disrupted at UCLA's Neuromodulation Lab.

Details one of the most elaborately staged theatrical productions in music history as Pink Floyd frontman Roger Waters performs the band's critically acclaimed album The Wall in its entirety.
The tour 'Roger Waters: The Wall' were performed from September 2010 to September 2013. The film have lots of footage from the concerts and other materials that have been filmed recently by Roger Waters – like his visit to his father’s grave in Italy that featured a film crew.

Foo Fighters prepare to record at the Austin City Limits Studio, with blues guitarist Gary Clark, Jr. In this episode is examined the roots of Austin's music scene, with interviews featuring Billy Gibbons from ZZ Top, and Roky Erickson from 13th Floor Elevators, who is considered one of the American fathers of psychedelic rock. Dave also chats with Terry Lickona, the executive producer of Austin City Limits. The song 'What Did I Do? / God As My Witness' is recorded during this chapter.

Los Angeles' highly influential position in rock history is examined. Pat Smear remembers the days of Germs, and visits legendary KROQ disc jockey Rodney Bingenheimer, owner of a 1970s Sunset Strip club that became the hub for the Los Angeles glam rock scene. Foo Fighters head to the desert to record their new song 'Outside', which features a solo from Eagles' guitarist Joe Walsh, at Rancho De La Luna, and in turn, Kyuss and the 1990s Palm Desert Scene is explored.

Dave Grohl discusses New Orleans' unique music history with Dr. John, Allen Toussaint and Cyril Neville. The band records in Preservation Hall and also performs with the Preservation Hall Jazz Band. The song 'In the Clear' is recorded during this episode.

Dave Grohl returns to his musical roots, while the Foo Fighters prepare to record at Seattle's Robert Lang Studio with Death Cab for Cutie's Benjamin Gibbard. Dave sets his focus on the Seattle music scene, mainly the grunge movement and its implications in American Rock Music. Interviews with Chris Cornell, Nancy Wilson, Bruce Pavitt.