Michael crosses Iran towards the Caspian Sea. He meets nomads who tell of Alexander's tryst with an Amazon queen, and the living descendants of Alexander's Persian enemies, who have their own tales of `Alexander the Accursed'.

Wood travels through war-torn Afghanistan, crossing the Oxus River into Central Asia and the Silk Road city of Samarkand where, in a drunken brawl, Alexander killed the friend who had previously saved his life.

The final leg takes him from the Khyber Pass through Pakistan to the Punjab, where Alexander's army mutinied and he was forced to return across the Makran Desert to Babylon, where he died at only 32 years of age.

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

During a Gurkha recruitment Palin is disturbed by Maoist insurgents, but survives to suffer as he climbs to 15,000 feet and sees the majesty of Annapurna Sanctuary. In Kathmandu he is blessed by the Nepalese king before meeting some holy men. Crossing into Tibet, he meets his first yaks at the highest monastery in the world, before heading up the Rongbuk glacier towards the summit of Everest.

Leaving Everest base camp to take the high road to Lhasa to see what the Chinese have done to Tibet. He sees that religion is once again tolerated, while the old Tibetan centre of the city is being replaced with modern Chinese shopping malls and nightclubs. Following the pilgrims to the holy Namtso Lake, he gets warm in a hot spring before learning how to milk a yak with a nomad family.