In the second part and conclusion, a spotlight on the mass marketing of the synthetic opioid fentanyl examines the connections between drug manufacturers and government policy. Video of sales retreats and promotional material reveals a deep cynicism among company employees and a disregard for the widespread, nefarious corporate practices.

Dr Chris van Tulleken, Dr Hannah Fry and Michael Mosley examine the latest research and explore some of the big questions about Covid-19 and the pandemic it has created. Michael visits the UK government's high-security laboratory Porton Down, where vaccines are being tested. He also uncovers what the experience of the 2002 SARs epidemic reveals about this one. Both were caused by coronaviruses, but certain key changes to today's virus have allowed it to infect the world, where SARs was contained.

It's this moment where now both sides realize that no quarter will be asked, and no quarter will be given. Surrender is no longer even an option. You're in this to the end. You either die or you triumph, and there is no other alternative. Amid a spiral of brutality and low morale, Mehmed makes Giustiniani an enticing offer. The grand vizier urges Mehmed to seek a truce with his rival.

Hours before Mehmed II launches his final assault, an ominous sight shakes both sides. Rumors of a 40-ship fleet's imminent arrival have swirled for weeks, but it's exact whereabouts remained unknown. Ottoman cannons reduced the city walls to rubble, and Venetian reinforcements arrived too late. The conquest of Constantinople ushers in a new era for the Ottoman Empire, being a dominant force in world politics for 300 years. Mehmed II, in many senses, changed the nature of world history.

Immense shoals of fish throng our shallow seas. Small fish, in turn, sustain bigger ones. The rich coastal seas are the fishing grounds of our planet and can provide an abundance of food for wildlife and humanity. The seas fringing land make up less than a tenth of the world's oceans but 90 percent of marine creatures live in coastal waters, from fearsome sharks to lowly urchins. Protecting these habitats is a battle humanity must win.

Bill Gates is on a mission. He needs to unlock the mysteries of the PDP-10 computer. But the adults won't share the source code with 13-year-old Bill. So he enlists his older friend Paul Allen. Together they boldly go where no one has gone before. If they find the source code, Bill and Paul will finally be able to master the computer.
The connections that shaped Bill Gates' life come into focus, including a childhood friendship and his unique bond with Microsoft co-founder Paul Allen.