Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

The theory of Némesis, a star that orbits the Sun and causes catastrophic events is explored. Nemesis is a hypothetical red dwarf or brown dwarf, originally postulated in 1984 to be orbiting the Sun at a distance of about 95,000 AU (1.5 light-years) somewhat beyond the Oort cloud, to explain a perceived cycle of mass extinctions in the geological record, which seem to occur more often at intervals of 26 million years.

Long ago, two species of human beings coexisted on Earth until competition drove one of them to extinction. This program, set in the southwest of France 35,000 years ago, reconstructs the life in the Neanderthal world at the time Cro-Magnons first entered the scene. All aspects of Neanderthal clan life are examined, including tool- and weapon-making, hunting and gathering, health and healing, childbirth, rituals, and making fire. Footage of skeletal remains and the scholarly research of eminent paleontologist Chris Stringer and Oxford University's Paul Pettitt support the documentary.

How is the universe put together? How is it built? And how does it actually work? How the Universe Works Series 8 shows the inner workings of our planet, the solar system, the galaxies and the universe itself.
In the first episode, if a massive asteroid collides with earth, it could end life on our planet as we know it. New discoveries and cutting-edge tech reveal just how close we are to apocalypse and what it would take for the world's leading space agencies to stop it.

What are the latest discoveries in the deadly world of asteroids? Will a recently returned Japanese spacecraft become the first to bring an asteroid sample back to our planet? What would happen to America's East Coast if the massive asteroid impact that helped form Chesapeake Bay 35 million years ago struck today? And why did President Barack Obama choose an asteroid as the destination for the next great manned mission into space? Learning about these huge space rocks isn't just about science, it's about survival.

Right now cosmic forces prowl the universe and threaten man's very existence. They're asteroids and comets; they've left their imprint on planet Earth, literally. Initially helping to build planets through violent collisions, during this fiery bombardment period they may have even seeded Earth with water and the building blocks for life. Since the turbulent formation of the solar system, these space rocks have continued to impact Earth. Some have been so violent that they've led to mass extinctions, including one that wiped out the dinosaur. New theories suggest that asteroid and comet dust harbour deadly viruses that may have triggered some of our worst pandemics. The possibility of future collisions remains a legitimate threat yet despite their dangers, asteroids and comets may hold vital natural resources, which could actually preserve