One hundred years after Columbus' arrival in the Caribbean, Spanish Conquistadors and Priests, push into North America in search of gold and to spread Catholicism. With the arrival of the British in North America, the two colonial systems produce contrasting societies that come in conflict as Manifest Destiny pushes the U.S into the Mexican territories of the South West. As the Gold Rush floods California with settlers, complex and vital communities are overwhelmed. The elites, including Mariano Vallejo and Apolinaria Lorenzana lose their land. Mexicans and Mexican Americans are treated as second-class citizens, facing discrimination and racial violence. Resistance to this injustice appears in New Mexico as Las Gorras Blancas (The White Caps), burn Anglo ranches and cut through barbed wire to prevent Anglo encroachment. At the same time, New Mexicans manage to transform themselves through education, managing to preserve Hispano culture in New Mexico and their standing in the midst of an era of conquest and dispossession.

Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

Sir David Attenborough reveals plants as they have never been seen before - on the move and dangerously devious. About the major problems of life - growing, finding food, reproduction - and the varied ways plants have evolved to solve it. Filmed from the plant's point of view, using computer animations, fibre-optics and unique time-lapse photography. The first episode looks at how plants are able to move". The bramble is an aggressive example: it advances forcefully from side to side and, once settled on its course, there is little that can stand in its way. An altogether faster species is the birdcage plant, which inhabits Californian sand dunes. When its location becomes exposed, it shifts at great speed to another one with the assistance of wind — and it is this that allows many forms of vegetation to distribute their seeds. While not strictly a plant, the spores of fungi are also spread in a similar fashion. One of the most successful (and intricate) flowers to use the wind is the dandelion, whose seeds travel with the aid of 'parachutes'. They are needed to travel miles away from their parents, who are too densely packed to allow any new arrivals. Trees have the advantage of height to send their seeds further, and the cottonwood is shown as a specialist in this regard. The humidity of the tropical rainforest creates transportation problems, and the liana-species Alsomitra macrocarpa is one plant whose seeds are aerodynamic 'gliders'. Some, such as those of the sycamore, take the form of 'helicopters', while others, such as the squirting cucumber release their seeds by 'exploding'. Water is also a widely used method of propulsion. The tropical sea bean Entada gigas has one of the biggest fruits of all plants and is dispersed by water streams. However, most plants use living couriers, whether they be dogs, humans and other primates, ants or birds, etc., and to that end, they use colour and smell to signify when they are ripe for picking.

Four years in the making, Life will set a new benchmark in family entertainment and natural history epics. Many animals and plants go to extremes to give themselves a chance. Aerial photography reveals how bottle-nosed dolphins trap fish in a ring of mud, and time-lapse cameras show how the Venus flytrap ensnares insect victims. The strawberry frog carries a tadpole high into a tree and drops it in a water-filled bromeliad. Fledgling chinstrap penguins undertake a heroic and tragic journey through the broken ice to get out to sea. Many can barely swim and the formidable leopard seal lies in wait

The documentary chronicles the fall of the Atari Corporation through the lens of one of the biggest mysteries of all time, dubbed 'The Great Video Game Burial of 1983'. As the story goes, the Atari Corporation, faced with an overwhelmingly negative response to 'E.T.', the video game for the Atari 2600, disposed of hundreds of thousands of unsold game cartridges by burying them in the small town of Alamogordo, New Mexico.