Following the wildly successful 'Cosmos: A Spacetime Odyssey,' Neil deGrasse Tyson returns as host to translate more revelations of science into a lavish transporting experience, taking audiences on a series of spiritual voyages of exploration. The show reveals previously uncharted realms, including lost worlds, worlds yet to come, and the worlds that humans may one day inhabit. Ann Druyan, original creative collaborator to Carl Sagan, whose iconic docuseries 'Cosmos' provided inspiration for this series, serves as executive producer alongside Seth MacFarlane.
Episode 1 takes viewers on a wild ride with the Ship of Imagination in an adventure spanning billions of years into the evolution of life.

The second episode takes a look at how humans have always been voyagers and explorers, leaving the comfort of native shores to explore. Neil DeGrasse Tyson will show us a long-term vision of humanity's future worlds.

Episode 3 delves into how life began on a roiling, violent Earth and explores the story behind Victor Goldschmidt, the man who found the first clues to life's beginnings on our planet. Neil deGrasse Tyson takes viewers on a journey through space and time to witness the tenacity and creativity of life on Earth and the prospects of life throughout the universe.

The fourth episode sees host Neil deGrasse Tyson exploring our eternal quest to end hunger and honoring Nikolai Ivanovic Vavilov, pioneer of modern plant breeding, who risked his life for a discovery that would change the history of science. Vavilov's story is marked by both the tenacity and creativity and is particularly tragic. Interwoven into Vavilov's somber narrative are warnings and treatments of science and its ethical implications, especially when science itself comes under attack from political forces.

In the fifth episode Neil deGrasse Tyson explores questions that have baffled scientists for centuries. Can we know the universe? Are our brains capable of comprehending the cosmos in all of its complexity and splendor?. We don't yet know the answers because our brain remains almost as much of a mystery to that questions as the universe itself. An abandoned orphan's dream opened the way to understanding the architecture of thought.

A child lies on the rug of a tenement dreaming of interstellar adventures. At the dawn of the space age, a young Carl Sagan’s career is forged in the clash of his mentors, two scientific titans. Sagan goes on realize his childhood dreams, to carry their research forward and communicate its significance to the whole world.