For one night only, Professor Brian Cox goes unplugged in a specially recorded programme from the lecture theatre of the Royal Institution of Great Britain. In his own inimitable style, Brian takes an audience of famous faces, scientists and members of the public on a journey through some of the most challenging concepts in physics. With the help of Jonathan Ross, Simon Pegg, Sarah Millican and James May, Brian shows how diamonds - the hardest material in nature - are made up of nothingness; how things can be in an infinite number of places at once; why everything we see or touch in the universe exists; and how a diamond in the heart of London is in communication with the largest diamond in the cosmos.

There is a strange and mysterious world that surrounds us, a world largely hidden from our senses. The quest to explain the true nature of reality is one of the great scientific detective stories. Clues have been pieced together from deep within the atom, from the event horizon of black holes, and from the far reaches of the cosmos. It may be that we are part of a cosmic hologram, projected from the edge of the universe. Or that we exist in an infinity of parallel worlds. Your reality may never look quite the same again.

Professor Brian Cox seeks to understand the nature of time and its role in creating both the universe and ourselves. From an extraordinary calendar built into the landscape of Peru to the beaches of Costa Rica, Brian explores the cycles of time which define our experience of life on Earth. But even the most epic cycles of life can't begin to compare to the vast expanse of cosmic time. Ultimately, Brian discovers that time is not characterised by repetition but by irreversible change. The vast universe is subject to these same laws of change. As we look out to the cosmos, we can see the story of its evolution unfold, from the death of the first stars to the birth of the youngest. This journey from birth to death will ultimately lead to the destruction not just of our planet, but also the entire universe, and with it the end of time itself. Yet without this inevitable destruction, the universe would be without what is perhaps the greatest wonder of all; the brief moment in time in which life can exist.

Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

The cycle of life of a handful of different animals is captured on film in a whole new way in this documentary. Using special motion-control photography equipment, Genesis allows filmgoers to view animal behaviors which are too small, too slow, or too difficult to normally be seen with the naked eye, including a chick hatching its way out from inside an egg, jellyfish drying into nothing under the heat of the sun, or a snake slowly swallowing prey bigger than itself. This footage is accompanied by narration from Sotigui Kouyate, who uses simple props and easily understandable analogies to explain the science behind what its shown on screen. Genesis was directed by Claude Nuridsany and Marie Perennou, who previously created another acclaimed scientific documentary, Microcosmos.