David Attenborough asks three key questions: how and why did Darwin come up with his theory of evolution? Why do we think he was right? And why is it more important now than ever before? David starts his journey in Darwin's home at Down House in Kent, where Darwin worried and puzzled over the origins of life. David goes back to his roots in Leicestershire, where he hunted for fossils as a child, and where another schoolboy unearthed a significant find in the 1950s. And he revisits Cambridge University, where both he and Darwin studied, and where many years later the DNA double helix was discovered, providing the foundations for genetics. At the end of his journey in the Natural History Museum in London, David concludes that Darwin's great insight revolutionised the way in which we see the world. We now understand why there are so many different species, and why they are distributed in the way they are. But above all, Darwin has shown us that we are not set apart from the natural world, and do not have dominion over it. We are subject to its laws and processes, as are all other animals on earth to which, indeed, we are related.

Professor Brian Cox grapples with science's darker side, asking why, when science has done so much for us, it often gets such a bad press. Starting with the original Frankenstein - the grisly 19th century tale of George Foster's hanging and subsequent 'electrocution', Brian confronts the idea that science can go 'too far'. From the nuclear bomb to genetic modification, British science has always been at the cutting edge of discovery, but are British scientists feckless meddlers, or misunderstood visionaries whose gifts to humanity are corrupted by the unscrupulous?

Dr Alice Roberts re-traces the greatest ever journey taken by our ancestors. Thousands of years ago one small group of our species, Homo sapiens, crossed out of Africa and into the unknown. Their descendants faced baking deserts, sweat-soaked jungles and frozen wildernesses and risked everything on the vast empty ocean. Within 60,000 years they colonised the whole world... How did they do it? Why do we, their descendants all look so different?

Dr Alice Roberts asks one of the great questions about our species: are we still evolving? There's no doubt that we're a product of millions of years of evolution. But thanks to modern technology and medicine, did we escape Darwin's law of the survival of the fittest? Alice follows a trail of clues from ancient human bones to studies of remarkable people living in the most inhospitable parts of the planet and the frontiers of genetic research, to discover if we are still evolving - and where we might be heading.

Richard Dawkins explores what science can tell us about death. It's a journey that takes him from Hindu funeral pyres in India to genetics labs in New York.Dawkins brings together the latest neuroscience, evolutionary and genetic theory to examine why we crave life after death, why we evolved to age and how the human genome is something like real immortality - traits inherited from our distant ancestors that we pass on to future generations.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).