Whether serving as Christian church, Islamic mosque, or secular museum, Hagia Sophia and its soaring dome have inspired reverence and awe. For 800 years, it was the largest enclosed building in the world—the Statue of Liberty can fit beneath its dome with room to spare. How has it survived its location on one of the world's most active seismic faults, which has inflicted a dozen devastating earthquakes since it was built in 537?" As Istanbul braces for the next big quake, a team of architects and engineers is urgently investigating Hagia Sophia's seismic secrets. Follow engineers as they build a massive 8-ton model of the building's core structure, place it on a motorized shake table, and hit it with a series of simulated quakes, pushing it collapse—a fate that the team is determined to avoid with the real building

The Ebola virus is one of the most virulent infections known to science. This special episode of Horizon meets the scientists and doctors from all around the world looking for the cure and hears first-hand accounts of what it is actually like to catch and survive the disease

Tom Service plunges into the life and times of Mozart to try and rediscover the greatness and humanity of the living man in his moment. Mozart's prodigious output and untimely death have helped place him on a pedestal that can often blind us to the unique brilliance of his work in the context of his life and times. Service visits the key cities and rooms in which Mozart lived and worked, plays some of Mozart's original instruments and scores, and gradually uncovers the brilliance and originality of his work." There is the prodigious childhood when Mozart was feted as an infant phenomenon around Europe's most glittering courts, and his golden decade in Vienna in which masterpiece followed masterpiece - operas, symphonies, piano concertos, string quartets - as if this short, high-voiced man-child must have been taking dictation from some divine source, until his death at the age of just 35 in 1791. Even more than the music, Mozart's tragic demise sets the seal on his myth. The trajectory of Mozart's life sets the template for the romantic paradigm whose throes we are still in today, which requires our creative heroes to die young to prove that they were too good for this madding world, whether it be Wolfgang Amadeus or Jimi Hendrix. Service travels from London to Vienna and Salzberg, unpicking the living, breathing genius that was Mozart. With Sir John Eliot Gardiner, Nicola Benedetti, Paul Morley and others.

Adam Rutherford meets a new creature created by American scientists, the spider-goat. It is part goat, part spider, and its milk can be used to create artificial spider's web. It is part of a new field of research, synthetic biology, with a radical aim: to break down nature into spare parts so that we can rebuild it however we please. This technology is already being used to make bio-diesel to power cars. Other researchers are looking at how we might, one day, control human emotions by sending 'biological machines' into our brains.

The documentary 'The Knowledge of Healing' is an illuminating examination of Tibetan medicine, a practice which has developed over two millennia into a modern day successful method of healing that rivals western medical practices. Unlike Western medicine, based on biochemistry, Tibetan medical thinking (which is strongly rooted in Buddhist principles) views the human body as governed by an elaborately organized system of energies flowing through a network of channels. In the 12th century, the Gyüshi (Knowledge of Healing) was created, a text codifying this intricate system. The medications used comprise herbs, roots, minerals, etc. After flourishing for centuries, most Tibetan medical schools were destroyed by the Chinese in the 1950's and 1960's, and many physicians were executed. Speaking from exile, the Dalai Lama argues for the value of Tibetan medicine, while his personal physician Dr. Tenzin Choedrak describes the principles behind it. We follow physicians in India and Siberia treating patients for a variety of ailments from paralysis to heart disease, and meet researchers in Israel and Switzerland to see how western clinical studies are testing the effectiveness of Tibetan medicine.

More than a decade ago, scientists announced that they had produced the first draft of the human genome, the 3.6 billion letters of our genetic code. It was seen as one of the greatest scientific achievements of our age, a breakthrough that would usher in a new age of medicine. Find out how close we are to developing the life-changing treatments that were hoped for". Follow three people, each with a genetic disease, as they go behind the scenes at some of Britain's leading research labs to find out what the sequencing of the human genome has done for them - and the hope this remarkable project offers all of us.