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The fourth episode starts off with the two riding through Santa Cruz, Argentina. The plan is to cross over into Chile and then going up into the Andes. Ewan and Charley head through Argentina’s red rock landscape while a member of their team copes with altitude sickness. The duo are well and truly underway and the first signs of all are well is how well the Harleys hold up in challenging conditions. The roads alternate between unforgiving and pleasant and these e-bikes push through effortlessly. As they ride through Chilean Andes, the audience is shown a picturesque view of the beauty of the countryside, an experience which Boorman calls 'magical.'

As the journey continues, there's beauty and danger in equal measure for Charley Boorman and Ewan McGrego. The duo ride their electric Harleys through the exotic and breathtaking Bolivian countryside in a tough ascent. The sixth episode showcases some of the challenges the hosts and the crew face when they scale the terrain. One of the Rivians runs into trouble while sandy roads and a heavy breeze sees Boorman take a tumble. Apart from all the accidents, the chapter also shows some quality work done by UNICEF when it comes to educating and working with the children in Bolivia.
The altitude sickness hits Taylor, their logistics man real bad and McGregor starts feeling it as well. The episode ends with a doctor heading to his hotel room to check up on him.

Most planets we know of are so hellish, it seems impossible that anything could live. But it's amazing where life can take hold in the Earth. Astrobiologists look for simple single-celled microbes known as extremophiles in places as Danakil Depression, known in Ethiopia as 'The Gateway to Hell.'
In Episode 2, the fictional world is Janus, a planet in such a close orbit than its rotation is locked by the star's gravity and it always shows the same face to its sun. On one side of the planet, it's always daytime, a searing desert. On the other side, it's forever night, a frozen shadowland. Squeezed between the two, a sliver of perpetual twilight. Freezing meltwater flows from the cold side, carving canyons through the landscape. Deep in these canyons lives an extraordinary five-legged creature.

Planets beyond our solar system are known to astronomers as exoplanets. They are at trillions of miles from Earth and yet, it might be possible to detect a faint signature of life in them. From the light of the stars they orbit that passes through the atmosphere of an exoplanet, it is possible to capture the chemical fingerprint of the elements in that atmosphere.
The fictional world Eden is orbiting not one star, but two. The light from its twin stars powers photosynthesis, pumping more oxygen into the atmosphere than in Earth, allowing life to thrive. Grazers are constantly alert to danger, because the canopy is home to predators perfectly evolved to live among the trees. In Episode 3, another topic are fungi and the role they could play on exoplanets. Ecologist Thomas Crowther talks about the role mycelial networks play in the Rothiemurchus forest in Scotland.

What sort of alien civilizations might exist in the vastness of space? Terra is the fictional world imagined in Episode 4, a planet nine billion years old, twice as old as Earth. Old enough that a truly advanced intelligence could evolve. It was once a fertile world, now it is barren. But life can still thrive here in artificial domes. Over time, they've evolved not to need their bodies. They exist only as neural tissue. They never age, they never die. They're monitored and maintained by robots.
If alien civilizations are statistically so likely, why haven't astronomers found any sign of them? Where is everyone? Every time we look at an individual star, that's like dropping a bucket in the ocean. We're going to have to look at a lot of stars and to search through a lot of data until we find the clue that leads us to another civilization.

It is the greatest technological challenge ever undertaken by humankind. The quest to produce the ultimate energy solution, Fusion, a reliable source of clean power. What if we could create here on earth, our very own version of a star, a machine that makes power from nuclear fuel? But so immense are the challenges, the goal of a power-producing fusion reactor has so far remained elusive and out of reach... until now.