Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, become the subject of scientific studies measuring the intense effects of its Psilocybin and its potential therapeutic use.
In the second episode, we are introduced to Ben, who’s battled with crippling Obsessive-Compulsive Disorder (OCD) his entire life. When he had his firstborn, Ben’s life became full of panic attacks regarding his son’s safety, and he knew something had to change. Ben signed up for a psilocybin-assisted therapy clinical trial which was testing whether the psychedelic could help people with severe OCD. In the session under the influence of psilocybin, Ben felt decomposed and eventually grew into a tree. While living as a tree, he saw his human self, playing with his child. Though this sounds scary, from Ben’s perspective, it was beautiful. He was one with the universe, seeing himself in the ultimate third-person perspective. Finally, he saw how it could be different if he didn’t let his OCD control him. And several months out, all the symptoms disappeared.
Ben’s story is one of many told in this series, which gives hope that help is right around the corner for the millions who suffer —often in silence— with debilitating mental disorders. But Michael Pollan’s work is showcasing the success stories. Often, even in the most successful trials, psychedelic-assisted therapy only helps up to a third of people enter remission. More frequently, patients are helped —sometimes substantially— but they still suffer with their illnesses and some people aren’t helped at all.

Even as the science grew more certain, the oil industry continued to block action to tackle climate change in the new millennium. In a revelatory interview, Christine Todd Whitman, George W. Bush's former environment chief, tells the story of how the industry successfully lobbied President Bush to reverse course on his campaign promise to regulate carbon emissions.
Tensions grew between two of the world's biggest oil companies, ExxonMobil and BP, after the latter publicly called for action to tackle climate change. The election of Barack Obama provided hope for supporters of climate action, but the billionaire Koch brothers made an effort to block the new president's attempts to pass climate change legislation, and climate denialism became the mainstream position of the Republican Party. A lawyer who worked for Koch brothers through this period speaks on camera for the first time.

The last chapter explains how the 2010s became another lost decade in the fight against climate change – as the move to natural gas delayed a transition to more renewable sources of energy.
Engineer Tony Ingraffea, in the 1980s, helped develop a new technique for extracting gas and oil from shale rock, which ultimately became known as 'Fracking'. It was to unleash vast new reserves of fossil fuels and was promoted as a cleaner energy source. But Ingraffea explains how he later came to regret his work when he realized that gas could be even worse for climate change than coal and oil.
Dar-Lon Chang, a former ExxonMobil engineer, speaks for the first time on camera alleging that as the company increased its natural gas operations, it was not sufficiently monitoring methane leaks that were contributing to climate change. Now, after a year of unprecedented wildfires, drought and other climate-related disasters, multiple lawsuits are being brought in US courts in efforts to hold Big Oil legally accountable for the climate crisis.

Chris has always worked to keep his body healthy; now it’s time to start looking after his brain. Neurologist Dr. Sharon Sha challenges him to go off-grid into the wilderness without a GPS or map. Teaming up with his buddy, First Nations artist Otis Hope Carey, Chris will need to tune into nature to navigate through Otis’ remote ancestral homeland. The hike stirs up Chris’s most precious memories.

Everyone's still reeling from the council's decision and its implications: the money Jeremy's spent on cows for the restaurant, the locals who won't find work there now and the farmers' co-operative that's now defunct. Charlie sets out to find a legal team to help Jeremy appeal the decision, as Jeremy and Kaleb get to work on tagging the new calves and attempting to navigate a government helpline where you're supposed to register them.
There are other useful distractions from the council in the shape of Diddly Squat's Hedge Laying Competition and a mouse that brings the whole farm to a standstill. The legal team that Charlie has assembled pay a visit. They outline their strategy for the appeal, but also the costs that come with it.

Spring has sprung at Diddly Squat Farm, and that heralds the release of cows and chickens from their winter captivity. Jeremy's restaurant plans are in tatters, but that's not the end of his dealings with the council, who are also sending letters raising issues about what's being sold in the shop itself. From here on in, Jeremy decides that he and all around him must operate in a world of loop-holes and just-within-the-law cunning wheezes. Pepper the prized heifer still isn't pregnant and her last chance saloon arrives in the shape of a bull called Break Heart Maestro.
A chat with Alan the builder provides a Eureka Moment: the restaurant idea is not dead after all! There's much excitement as building work begins and Jeremy meets a chef called Pip. There's less excitement when he has to take his first steer to the abattoir.