The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

The episode, devoted to the planet Mars, begins with scientific and fictional speculation about the Red Planet during the late nineteenth and early twentieth centuries (H. G. Wells' The War of the Worlds, Edgar Rice Burroughs' science fiction books, and Percival Lowell's false vision of canals on Mars). It then moves to Robert Goddard's early experiments in rocket-building, inspired by reading science fiction, and the work by Mars probes, including the Viking, searching for life on Mars. The episode ends with the possibility of the terraforming and colonization of Mars and a Cosmos Update on the relevance of Mars' environment to Earth's and the possibility of a manned mission to Mars.

Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

In the 80s the nature of the Latino Diaspora changes again. From Cuba a second wave of refugees to United States – the Mariel exodus – floods Miami . The same decade sees the sudden arrival of hundreds of thousands of Central Americans (Salvadorans, Guatemalans, and Nicaraguans) fleeing death squads and mass murders at home like activist, Carlos Vaquerano. By the early 1990s, a political debate over illegal immigration – has begun. Globalization, empowered by NAFTA, means that as U.S. manufacturers move south, Mexican workers head north in record numbers. A backlash ensues: tightened borders, anti-bilingualism, state laws to declare all illegal immigrants felons. But a sea change is underway: the coalescence of a new phenomenon called Latino American culture-as Latinos spread geographically and make their mark in music, sports, politics, business, and education.

This episode explores the wave theory of light as studied by mankind, noting that light has played an important role in scientific progress, with such early experiments from over 2000 years ago involving the camera obscura by the Chinese philosopher Mozi. Tyson describes the work of the 11th century Arabic scientist Ibn al-Haytham, considered to be one of the first to postulate on the nature of light and optics leading to the concept of the telescope, as well as one of the first researchers to use the scientific method. Tyson proceeds to discuss the nature of light as discovered by mankind. Work by Isaac Newton using diffraction through prisms demonstrated that light was composed of the visible spectrum, while findings of William Herschel in the 19th century showed that light also consisted of infrared rays. Joseph von Fraunhofer would later come to discover that by magnifying the spectrum of visible light, gaps in the spectrum would be observed. These Fraunhofer lines would later be determined to be caused by the absorption of light by electrons in moving between atomic orbitals when it passed through atoms, with each atom having a characteristic signature due to the quantum nature of these orbitals. This since has led to the core of astronomical spectroscopy, allowing astronomers to make observations about the composition of stars, planets, and other stellar features through the spectral lines, as well as observing the motion and expansion of the universe, and the existence of dark matter.

Michael crosses Iran towards the Caspian Sea. He meets nomads who tell of Alexander's tryst with an Amazon queen, and the living descendants of Alexander's Persian enemies, who have their own tales of `Alexander the Accursed'.