Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Every cosmologist and astronomer agrees: our Universe is 13.7 billion years old. Using cutting-edge technology, scientists are now able to take a snapshot of the Universe a mere heartbeat after its birth. Armed with hypersensitive satellites, astronomers look back in time to the very moment of creation, when all the matter in the Universe exploded into existence. It is here that we uncover an unsolved mystery as old as time itself -- if the Universe was born, where did it come from? Meet the leading scientists who have now discovered what they believe to be the origin of our Universe, and a window into the time before time.

In episode two, Professor Brian Cox is off to India, where he assesses arguably the first evidence of rational thought in literature, the poetry of the Vedic monks. They pondered mankind's origins, realising there must have been a day with no yesterday - a day of creation - prompting the age-old question of where did the universe come from? Brian marvels that the universe seems to follow a set of rules, the laws of physics, allowing space to be considered on the grandest scale, travelling to the most distant, farthest reaches of the cosmos just by using our minds. Brian also visits Japan, and offers viewers the idea that man lives in just one of an infinite number of universes that are being made all the time.

Mathematician Dr Hannah Fry explores the mystery of maths. It underpins so much of our modern world that it's hard to imagine life without its technological advances, but where exactly does maths come from? Is it invented like a language or is it something discovered and part of the fabric of the universe? It's a question that some of the most eminent mathematical minds have been wrestling with. To investigate this question, Hannah goes head first down the fastest zip wire in the world to learn more about Newton's law of gravity, she paraglides to understand where the theory of maths and its practice application collide, and she travels to infinity and beyond to discover that some infinities are bigger than others.
In this episode, Hannah goes back to the time of the ancient Greeks to find out why they were so fascinated by the connection between beautiful music and maths. The patterns our ancestors found in music are all around us, from the way a sunflower stores its seeds to the number of petals in a flower. Even the shapes of some of the smallest structures in nature, such as viruses, seem to follow the rules of maths. All strong evidence for maths being discovered. But there are those who claim maths is all in our heads and something we invented. To find out if this is true, Hannah has her brain scanned. It turns out there is a place in all our brains where we do maths, but that doesn't prove its invented.
Experiments with infants, who have never had a maths lesson in their lives, suggests we all come hardwired to do maths. Far from being a creation of the human mind, this is evidence for maths being something we discover. Then along comes the invention of zero to help make counting more convenient and the creation of imaginary numbers, and the balance is tilted in the direction of maths being something we invented. The question of whether maths is invented or discovered just got a whole lot more difficult to answer

Professor Brian Cox journeys across the vastness of time and space revealing epic moments of sheer drama that changed the universe forever.
The series begins this epic exploration of the cosmos with a hymn to the great luminous bodies that bring light and warmth to the universe: the stars. It is estimated that there are two hundred trillion stars in the universe, each playing their part in an epic story of creation- a great saga that stretches from the dawn of time, with the arrival of the first star, through diverse generations until the arrival of our own star, the sun, and a civilization that has grown up in its light.

In part two, Professor Al-Khalili looks at the 19th century chemists who struggled to impose an order on the apparently random world of the elements. From working out how many there were to discovering their unique relationships with each other, the early scientists' bid to decode the hidden order of the elements was driven by false starts and bitter disputes. But ultimately the quest would lead to one of chemistry's most beautiful intellectual creations - the periodic table.