The biggest rabbit-hole in history: the search of the smallest thing in the Universe. It is a journey where things don't just become smaller but also a whole lot weirder. Scientists hope to catch a glimpse of miniature black holes, multiple dimensions and even parallel Universes. As they start to explore this wonderland, where nothing is quite what it seems, they may have to rewrite the fundamental laws of time and space.

Our universe seems real. But what if it’s a videogame? Scientists in a variety of fields are taking seriously the possibility that we live in a virtual reality. Maybe the Big Bang was just the moment someone flipped the switch and turned on our universe. Maybe what looks random has already been programmed to happen. If some advanced civilization did design and program our universe, would we ever know? Scientists are looking for glitches in the laws of the universe that may uncover its hidden code.

From the Philippines to the US, Madagascar and Mexico, Professor Brian Cox explores the globe to reveal how a few fundamental laws of science gave birth to the most complex and unique feature of the universe - life. In the first episode, Brian journeys to the volcanic landscapes of South-East Asia, seeking to understand how life first began and how that spark has endured to this day.

This scientific detective tale tells the story of a remarkable group of pioneers who wanted to reach the ultimate extreme: absolute zero, a place so cold that the physical world as we know it doesn't exist, electricity flows without resistance, fluids defy gravity and the speed of light can be reduced to 38 miles per hour. Absolute zero became the Holy Grail of temperature physicists and is considered the gateway to many new technologies, such as nano-construction, neurological networks and quantum computing. The possibilities, it seems, are limitless. The first episode Chronicles the major discoveries leading towards the mastery of cold, beginning with King James I's court magician, Cornelius Drebbel, who managed to air condition the largest interior space in the British Isles in 1620. Other stories will include the first "natural philosopher," Robert Boyle, a founder of the Royal Society in Great Britain; the Grand Duke Ferdinand II de Medici's involvement in the creation of the first thermometer; the establishment of the laws of thermodynamics by three young scientists, Sadi Carnot, James Joule and William Thomson; and Michael Faraday's critical achievement in liquefying several other gases which set the stage for the commercial application of cold to refrigeration and air conditioning.

Professor of physics Jim Al-Khalili investigates the most accurate and yet perplexing scientific theory ever - quantum physics, the perplexing theory of sub-atomic particles. Turning his attention to the world of nature, can quantum mechanics explain the greatest mysteries in biology? The European robin navigates using one of the most bizarre effects in physics - quantum entanglement, a process which seems to defy common sense. Jim finds that even the most personal of human experiences - our sense of smell - is touched by ethereal quantum vibrations. According to new experiments it seems that our quantum noses are listening to smells. Jim discovers that the most famous law of quantum physics - the uncertainty principle - is obeyed by plants and trees as they capture sunlight during the vital process of photosynthesis. Jim wonders if the strange laws of the sub-atomic world, which allow objects to tunnel through impassable barriers in defiance of common sense, could effect the mechanism by which living species evolve?

Professor Brian Cox seeks to understand the nature of time and its role in creating both the universe and ourselves. From an extraordinary calendar built into the landscape of Peru to the beaches of Costa Rica, Brian explores the cycles of time which define our experience of life on Earth. But even the most epic cycles of life can't begin to compare to the vast expanse of cosmic time. Ultimately, Brian discovers that time is not characterised by repetition but by irreversible change. The vast universe is subject to these same laws of change. As we look out to the cosmos, we can see the story of its evolution unfold, from the death of the first stars to the birth of the youngest. This journey from birth to death will ultimately lead to the destruction not just of our planet, but also the entire universe, and with it the end of time itself. Yet without this inevitable destruction, the universe would be without what is perhaps the greatest wonder of all; the brief moment in time in which life can exist.