As man moves to colonize the cosmos, the realities of sexual relationships and reproduction need to be addressed. Probe the physiological, psychological and cultural challenges of sex in space.

Alex Gibney explores the charged issue of pedophilia in the Catholic Church, following a trail from the first known protest against clerical sexual abuse in the United States and all the way to the Vatican. The title is derived from the Latin phrase "mea maxima culpa". It is taken from the Confiteor that is part of the Roman Catholic Mass. It translates into English as "My most grievous fault" The film examines the abuse of power in the Catholic Church system through the story of four deaf men who set out to expose the priest who abused them during the mid-1960s. Each of the men brought forth the first known case of public protest against clerical sex abuse, which later lead to the sex scandal case known as the Lawrence Murphy case. Through their case the film follows a cover-up that winds its way from the row houses of Milwaukee, Wisconsin, through Ireland's churches, all the way to the highest office of the Vatican.

The film is an urgent real-life drama that examines the ripple effects on families, friends, schools and communities when two underage young women find that sexual assault crimes against them have been caught on camera. From acclaimed filmmakers Bonni Cohen and Jon Shenk (The Island President, The Rape of Europa), AUDRIE & DAISY takes a hard look at American’s teenagers who are coming of age in this new world of social media bullying, spun wildly out of control.

The Internet enables us to connect with people, images and information in ways that were unimaginable 30 years ago. But with every click we are re-wiring the physical structure of our brains. Are we evolving or actively de-evolving down a dopamine-laced click-hole? In this episode meet a 17-year-old boy struggling with an addiction to online pornography; autistic technologists in Silicon Valley who are turning their genetic variation to an advantage; plus, Nootropics, a class of cognition-enhancing supplements that claims to rewire the brain.

Boy or girl? It’s the eternal question. But that question may have more than two answers. Science reveals the line between male and female is blurred. And the battle of the sexes is happening deep within our cells. Are there more than two sexes?

In the second episode, Nathan develops a rehearsal for Angela, a woman considering motherhood. Nathan hires child actors to simulate adopting and caring for a baby and sets her up in a rented farmhouse in rural Oregon. Due to Oregon child protection laws, Nathan's team must covertly switch out the baby every four hours and replace it with a robot baby at night. Seeking a simulated husband, Angela dates Robbin, a numerology-obsessed man who wants to have sex with Angela despite her devout Christian beliefs against premarital sex. When Robbin quits the project due to the robot baby's incessant crying, Nathan inserts himself into the experiment as Angela's non-romantic co-parent.