We are in the grip of an allergy epidemic. 50 years ago one in 30 were affected, but in Britain today it is closer to one in three. Why this should be is one of modern medicine's greatest puzzles. In search of answers, Horizon travels round the globe, from the remotest inhabited island to the polluted centres of California and the UK. We meet sufferers and the scientists who have dedicated their lives trying to answer the mystery of why we are becoming allergic to our world.

Dr Alice Roberts asks one of the great questions about our species: are we still evolving? There's no doubt that we're a product of millions of years of evolution. But thanks to modern technology and medicine, did we escape Darwin's law of the survival of the fittest? Alice follows a trail of clues from ancient human bones to studies of remarkable people living in the most inhospitable parts of the planet and the frontiers of genetic research, to discover if we are still evolving - and where we might be heading.

The terrorist group Boko Haram is responsible for thousands of deaths in Nigeria. Now, the government is determined to drive these militants from the country. But is the hunt for insurgents causing as much harm as it's preventing? Former Navy SEAL and new VICE correspondent Kaj Larsen travels to Nigeria to see what this cat-and-mouse game means for the people caught in the middle of the fight. 'Unnatural Selection': For centuries, scientists have been working to change the genetic traits of plants and animals. Now, the new gene-editing method CRISPR has made that process astonishingly simple - so simple it could easily be used on humans. Isobel Yeung reports from Brazil, Scotland, China and the U.S. on the technological advances that could reshape evolution as we know it.

At an extraordinary moment in the history of one of the world’s oldest and most controversial drugs, Dr Javid Abdelmoneim investigates the very latest medical and scientific research into the effects of cannabis on the brain and the body, to find out whether it will help or harm patients.
Javid meets the young epilepsy patient responsible for changing the law around medicinal cannabis in the UK and sees the remarkable effects it has on his condition. He visits a medicinal cannabis farm in Denmark to learn how a company known for growing the recreational drug are now producing medicinal cannabis to be exported all over Europe. He travels to Israel, to find out why they have been using cannabis as a medicine for over 20 years and meets the scientists studying the safety and effectiveness of cannabis in treating pain. And he meets the so-called godfather of cannabis, who at 88 years old is still an active research scientist and considered the world’s leading cannabis expert.

Cannabis is the world's favourite drug, but also one of the least understood. Can cannabis cause schizophrenia? Is it addictive? Can it lead you on to harder drugs? Or is it simply a herb, an undervalued medicine? Addiction specialist Dr John Marsden discovers that modern science is finally beginning to find answers to these questions. John traces the cannabis plants' birthplace in Kazakhstan; finds the origins of our sensitivity to cannabis in the simple sea squirt; and finds out just what it does to our brains. He meets people who have been changed by this drug in drastically different ways - from those whose lives have been shattered to those who lives have been revived.

The last episode explores Mescaline, the psychoactive molecule in San Pedro and peyote cacti, a sacred medicine that Native Americans have had to fight for the right to use. At the Indigenous practices there's always an elder, someone who knows the territory very well, who's presiding. There's usually a group, a community is involved, There's always an intention, a purpose to what you're doing, and you're treating it as sacred, in order to achieve altered states of consciousness, which contribute to worship in various ways, or celebration or healing.
But maybe all this is not so new to Western culture after all. In the old Greek histories of Eleusis, people who were initiated there got the drink, the kykeon, and then they had the illumination. The precise recipe is a mystery, but we know that the kykeon was a psychoactive brew that was used at the Eleusinian mysteries, a sacred annual ritual of enlightenment practiced by some of the world's greatest minds including Socrates, Plato, and Aristotle. So why did this ritual come to an end more than 1,000 years ago? Was the possibility of illumination or achieving a higher consciousness considered threatening to the powers that be? Have the drug wars been merely an extension of that fear?
Psychedelics has a major part in how we can heal as a community, how we can heal as a city, and how we can heal as a country. The current renaissance of psychedelics could not come at a better time as the world confronts a crisis in mental health. But psychedelics have much to offer. The psychedelic experience changes the mind in ways that will help scientists better understand how it works. All these altered states allow us to probe what is the greatest mystery in all of nature. The emergence from mere matter of something as miraculous as consciousness. But an even bigger question is whether psychedelics might help us address the environmental crisis of how we think about our place in nature. One of the greatest gifts of psychedelics is how they reanimate the natural world, allowing us to perceive the subject, the spirit of all species, not just our own. And to feel a deeper sense of interconnectedness with nature.