Without the chemistry of photosynthesis, ozone, and a molecule called Rubisco, none of us would be here. So how did we get so lucky? To find out, host David Pogue investigates the surprising molecules that allowed life on Earth to begin, and ultimately thrive. Along the way, he finds out what we’re all made of—literally.

Just 92 elements made up the world, but the belief that were only four - earth, fire, air and water - persisted until the 19th Century. Professor Al-Khalili retraces the footsteps of the alchemists who first began to question the notion of the elements in their search for the secret of everlasting life.He reveals the red herrings and rivalries which dogged scientific progress, and explores how new approaches to splitting matter brought us both remarkable elements and the new science of chemistry.

In part two, Professor Al-Khalili looks at the 19th century chemists who struggled to impose an order on the apparently random world of the elements. From working out how many there were to discovering their unique relationships with each other, the early scientists' bid to decode the hidden order of the elements was driven by false starts and bitter disputes. But ultimately the quest would lead to one of chemistry's most beautiful intellectual creations - the periodic table.

In the final part, Professor Al-Khalili uncovers tales of success and heartache in the story of chemists' battle to control and combine the elements, and build our modern world. He reveals the dramatic breakthroughs which harnessed their might to release almost unimaginable power, and he journeys to the centre of modern day alchemy, where scientists are attempting to command the extreme forces of nature and create brand new elements.

Of the four elements, air is the most elusive because we can't see it. There's something very magical about it. One of the ways we transform food is by getting air into it. Think of the soufflé, think of the loaf of bread. These things are elevated by the fact that they now contain air. They're ethereal. Visit food labs and Moroccan fields as Michael Pollan delves into the science of bread-making and the nature of gluten.

Planets beyond our solar system are known to astronomers as exoplanets. They are at trillions of miles from Earth and yet, it might be possible to detect a faint signature of life in them. From the light of the stars they orbit that passes through the atmosphere of an exoplanet, it is possible to capture the chemical fingerprint of the elements in that atmosphere.
The fictional world Eden is orbiting not one star, but two. The light from its twin stars powers photosynthesis, pumping more oxygen into the atmosphere than in Earth, allowing life to thrive. Grazers are constantly alert to danger, because the canopy is home to predators perfectly evolved to live among the trees. In Episode 3, another topic are fungi and the role they could play on exoplanets. Ecologist Thomas Crowther talks about the role mycelial networks play in the Rothiemurchus forest in Scotland.