The dome that crowns Florence's great cathedral of Santa Maria del Fiore, the Duomo, is a masterpiece of Renaissance ingenuity and an enduring source of mystery. Still the largest masonry dome on earth, it is taller than the Statue of Liberty and weighs as much as an average cruise ship. Historians and engineers have long debated how its architect, Filippo Brunelleschi, kept the dome perfectly aligned and symmetrical as the sides rose and converged toward the center." More than four million bricks could collapse at any moment -- and we still don't understand how Brunelleschi prevented it. To test the latest theories, a team of U.S. bricklayers will help build an experimental "mini-Duomo" using period tools and techniques.

In the fourth part of the series, Diarmaid MacCulloch makes sense of the Reformation, and of how a faith based on obedience and authority gave birth to one based on individual conscience. He shows how Martin Luther wrote hymns to teach people the message of the Bible, and how a tasty sausage became the rallying cry for Swiss Reformer Ulrich Zwingli to tear down statues of saints, allow married clergy and deny that communion bread and wine were the body and blood of Christ.

Professor Brian Cox grapples with science's darker side, asking why, when science has done so much for us, it often gets such a bad press. Starting with the original Frankenstein - the grisly 19th century tale of George Foster's hanging and subsequent 'electrocution', Brian confronts the idea that science can go 'too far'. From the nuclear bomb to genetic modification, British science has always been at the cutting edge of discovery, but are British scientists feckless meddlers, or misunderstood visionaries whose gifts to humanity are corrupted by the unscrupulous?

The final episode of this series looks at what happens to the brain when someone uses psychedelic drugs. It looks at how psychedelic drugs may be useful in dealing with anxiety in cancer survivors and serious depression. It explores the history of psychedelics and examines early medical experimentation with the drug. It also discussed why psychedelics were banned and examines how they affect the brain.

Jungles provide the richest habitats on the planet - mysterious worlds of high drama where extraordinary animals attempt to survive in the most competitive place on earth. Flooded forests are home to caiman-hunting jaguars and strange dolphins that swim amongst the tree tops, while in the dense underworld, ninja frogs fight off wasps and flying dragons soar between trees. Acrobatic indri leap through the forests of Madagascar, while the jungle night conceals strange fungi and glow-in-the-dark creatures never filmed before.

In the dark depths of the oceans, nearly 90% of all species light up the darkness from within. These creatures flash, sparkle, shimmer, or simply glow. Whether it’s to scare off predators, fish for prey, or lure a mate, the language of light is everywhere in the ocean depths, and scientists are finally starting to decode it. Discover surprising ways to harness nature’s light—from tracking cancer cells to detecting pollution, lighting up cities, and even illuminating the inner workings of our brains.