Quinto sets out to discover whether aliens exist and what evidence we have to prove it. He meets with several who say they have encountered extra-terrestrial life–a man who has been abducted by aliens several times since childhood; a man who claims to have extracted an alien implant; and a woman who shows Zachary what it feels like to be abducted into a spacecraft.
Zachary also meets with the world's leading scientists at SETI in Green Banks, West Virginia. There, utilizing the world's largest telescope, they show him the methods they employ to communicate with potential other-worldly visitors and what this research has taught them about a mysterious radio signal they picked up 3 billion light years away.

They've discovered water on other planets, and snatched the actual building blocks of life from a comet's tail. But can space probes find a new Earth...and even make contact with alien life? In the 21st century, space probes are photographing, drilling and even sniffing new worlds in the quest for life, and scanning thousands of distant suns trying to detect Earth-like planets. It's only a matter of time before space probes unlock the secrets to extra-terrestrial life and the universe itself.

Are we alone? SETI--the Search for Extraterrestrial Intelligence--is a privately funded project using radio telescopes and optical telescopes to scan the stars for signals.

In the fifth episode of the series, as Steven's trial begins, his attorneys argue that law enforcement officials framed him and were negligent in not pursuing other leads in the case.

Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, become the subject of scientific studies measuring the intense effects of its Psilocybin and its potential therapeutic use.
In the second episode, we are introduced to Ben, who’s battled with crippling Obsessive-Compulsive Disorder (OCD) his entire life. When he had his firstborn, Ben’s life became full of panic attacks regarding his son’s safety, and he knew something had to change. Ben signed up for a psilocybin-assisted therapy clinical trial which was testing whether the psychedelic could help people with severe OCD. In the session under the influence of psilocybin, Ben felt decomposed and eventually grew into a tree. While living as a tree, he saw his human self, playing with his child. Though this sounds scary, from Ben’s perspective, it was beautiful. He was one with the universe, seeing himself in the ultimate third-person perspective. Finally, he saw how it could be different if he didn’t let his OCD control him. And several months out, all the symptoms disappeared.
Ben’s story is one of many told in this series, which gives hope that help is right around the corner for the millions who suffer —often in silence— with debilitating mental disorders. But Michael Pollan’s work is showcasing the success stories. Often, even in the most successful trials, psychedelic-assisted therapy only helps up to a third of people enter remission. More frequently, patients are helped —sometimes substantially— but they still suffer with their illnesses and some people aren’t helped at all.

Where is everyone? We have been listening for messages from outer space for more than half a century, and so far... silence, why? Are we truly alone in the universe? Or is everyone else acting like us and just doing a lot of listening? Maybe we need to be louder. Maybe we need to send more messages out there. But how do you write a letter to an extraterrestrial whose language and culture and biology and mind we have no concept of? And what do you say?
Given all of the unknowns about what they might behave, should we say anything at all?