Beginning with the separation of the fuzzy thinking and pious fraud of astrology from the careful observations of astronomy, Sagan follows the development of astronomical observation. Beginning with constellations and ceremonial calendars (such as those of the Anasazi), the story moves to the debate between Earth and Sun-centered models: Ptolemy and the geocentric worldview, Copernicus' theory, the data-gathering of Tycho Brahe, and the achievements of Johannes Kepler (Kepler's laws of planetary motion and the first science-fiction novel).

In the last episode, Al-Khalili turns detective, hunting for clues that show how the scientific revolution that took place in the 16th and 17th centuries in Europe had its roots in the earlier world of medieval Islam. He travels across Iran, Syria and Egypt to discover the huge astronomical advances made by Islamic scholars through their obsession with accurate measurement and coherent and rigorous mathematics.He then visits Italy to see how those Islamic ideas permeated into the west and ultimately helped shape the works of the great European astronomer Copernicus, and investigates why science in the Islamic world appeared to go into decline after the 16th and 17th centuries, only for it to re-emerge in the present day. Al-Khalili ends his journey in the Royan Institute in the Iranian capital Tehran, looking at how science is now regarded in the Islamic world