Dr Michael Mosley traces the sinister ways the experimental psychology has used to try to control our minds. He finds that the pursuit of mind control has led to some truly horrific experiments and left many casualties in its wake. Extraordinary archive captures what happened - scientists systematically change the behaviour of children; law abiding citizens give fatal electric shocks; a gay man has electrodes implanted in his head in an attempt to turn his sexuality. Michael takes a hallucinogenic drug as part of a controlled experiment to try to understand how its mind-bending properties can change the brain. This is a scientific journey goes to the very heart of what we hold most dear - our free will, and our ability to control our own destiny.

The final episode of this series looks at what happens to the brain when someone uses psychedelic drugs. It looks at how psychedelic drugs may be useful in dealing with anxiety in cancer survivors and serious depression. It explores the history of psychedelics and examines early medical experimentation with the drug. It also discussed why psychedelics were banned and examines how they affect the brain.