This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

In August 1977, the Big Ear Radio-telescope in Ohio received a strange signal from the Sagittarius constellation while searching for intelligent extra-terrestrial life. It had a duration of 72 seconds and an intensity 30 times higher than usual. Named the Wow signal, it is still being considered as one of the best examples of having being sent by intelligent extraterrestrial life. But, nothing has revolutionised the search of extra-terrestrial intelligent life as much as the recent discovery by the Kepler Satellite, of thousands of Earth-like planets where life could be possible. Join the debate with this stunning documentary, as we ask Is Anybody Out There?

Is mankind alone, or are there aliens out there, either waiting to be discovered, or on their way to find Earth? Professor Brian Cox spends this episode asking such questions, and what he discovers may raise a few eyebrows. He begins by exploring the human race's efforts to find neighbours in outer space, including the launch of two golden discs containing a greeting from Earth in the 1970s; they are still travelling and are now the most distant man-made objects from the planet. Brian also meets members of the Search for Extra-Terrestrial Intelligence, who have been monitoring radio signals for 50 years without success, before discussing the ingredients needed to make an intelligent civilisation with astrophysicist Dr Frank Drake.

Questions are raised about the search for intelligent life beyond the Earth, with UFOs and other close encounters refuted in favor of communications through SETI and radio telescope such as the Arecibo Observatory. The probability of technically advanced civilizations existing elsewhere in the Milky Way is interpreted using the Drake equation and a future hypothetical Encyclopedia Galactica is discussed as a repository of information about other worlds in the galaxy. The Cosmos Update notes that there have been fewer sightings of UFOs and more stories of abductions, while mentioning the META scanning the skies for signals.

What sort of alien civilizations might exist in the vastness of space? Terra is the fictional world imagined in Episode 4, a planet nine billion years old, twice as old as Earth. Old enough that a truly advanced intelligence could evolve. It was once a fertile world, now it is barren. But life can still thrive here in artificial domes. Over time, they've evolved not to need their bodies. They exist only as neural tissue. They never age, they never die. They're monitored and maintained by robots.
If alien civilizations are statistically so likely, why haven't astronomers found any sign of them? Where is everyone? Every time we look at an individual star, that's like dropping a bucket in the ocean. We're going to have to look at a lot of stars and to search through a lot of data until we find the clue that leads us to another civilization.

Brian Cox looks at our attempts to answer one of the most profound questions we can ask – are we alone in the universe? With scientists sending space probes to the furthest reaches of our solar system and beyond, the scientific search for alien life has begun. Inspired by a childhood love of science fiction, Brian still hopes to hear from ET. In this film, he explains why this search deserves to be taken seriously, and he explores the chances of it happening.