The cycle of life of a handful of different animals is captured on film in a whole new way in this documentary. Using special motion-control photography equipment, Genesis allows filmgoers to view animal behaviors which are too small, too slow, or too difficult to normally be seen with the naked eye, including a chick hatching its way out from inside an egg, jellyfish drying into nothing under the heat of the sun, or a snake slowly swallowing prey bigger than itself. This footage is accompanied by narration from Sotigui Kouyate, who uses simple props and easily understandable analogies to explain the science behind what its shown on screen. Genesis was directed by Claude Nuridsany and Marie Perennou, who previously created another acclaimed scientific documentary, Microcosmos.

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

Travel from the inner solar system to the Kuiper Belt and explore the moons surrounding the planets of the solar system. Many of these moons that were once unknown are now on the cutting edge of astronomical study. Some burst with volcanic fury another spews icy geysers and others offer the possibility of alien life. Are these strange worlds simply hostile environments unfit for humans or do other possibilities exist? Cutting-edge computer graphics are used to bring the universe down to earth and to imagine what kind of life forms might evolve in alien atmospheres.

Blue whales are the largest animals to ever live on earth, yet they are difficult to find or track. Even some of the locations where they birth their young are great secrets. Join some of the world's eminent blue whale scientists as they embark on a revolutionary mission to identify and tag California blue whales as they migrate to a spot known as the Costa Rica Dome. This incredible voyage yields unforgettable new footage and insight into these amazing creatures' lives. Scientists use DNA analysis, recordings of whale songs, homing devices, and sea dives to shed light on the blue whale's breeding and birthing habits

Horizon discovers what your cat really gets up to when it leaves the cat flap. In a groundbreaking experiment, 50 cats from a village in Surrey are tagged with GPS collars and their every movement is recorded, day and night, as they hunt in our backyards and patrol the garden fences and hedgerows. Cats are fitted with specially developed cat-cams which reveal their unique view of our world. You may think you understand your pet, but their secret life is more surprising than we thought.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).