The fourth episode starts off with the two riding through Santa Cruz, Argentina. The plan is to cross over into Chile and then going up into the Andes. Ewan and Charley head through Argentina’s red rock landscape while a member of their team copes with altitude sickness. The duo are well and truly underway and the first signs of all are well is how well the Harleys hold up in challenging conditions. The roads alternate between unforgiving and pleasant and these e-bikes push through effortlessly. As they ride through Chilean Andes, the audience is shown a picturesque view of the beauty of the countryside, an experience which Boorman calls 'magical.'

Operation Condor was a campaign of political repression and terror involving intelligence operations and assassination of opponents, officially implemented in 1975 by the right-wing dictatorships of the Southern Cone of South America. The program was intended to eradicate communist or Soviet influence and ideas, and to suppress active or potential opposition movements against the participating governments.

Alice Roberts tries to find out how Stone Age people reached North and South America for the first time. She finds out about an ancient corridor through the Canadian ice sheet that might have allowed the first humans through. Old finds in Chile though point to a whole different route for the first humans making it there.