Thirty years after his film JFK, filmmaker Oliver Stone takes viewers on a journey though recently declassified evidence in the assassination of President Kennedy -- the most consequential American murder mystery of the twentieth century. Joined by Whoopi Goldberg and Donald Sutherland, as well as a distinguished team of forensics, medical and ballistics experts, historians, and witnesses, Stone presents compelling evidence that in the Kennedy case 'conspiracy theory' is now 'conspiracy fact.'

From Patrick Kennedy's emigration in 1849 to the death of JFK Jr. in 1999, the films charts the family's rise from poor Irish immigrants to an all-powerful dynasty, exploring the lives, careers, personal tragedies and scandals that have given rise to the idea of a Kennedy curse.
Featuring interviews with family members, and including rare archive, photos and letters, 'The Kennedys: A Fatal Ambition' sets the events in historical context, examines the family's unique characteristics and asks what part they may have played in many of the misfortunes.

JFK and the Bay of Pigs; on the brink of total war during Cuban Missile Crisis; early Vietnam; JFK's attempts at peace with Khrushchev; JFK assassinated.

Stone opens the episode on Vietnam with a review of American intervention in Latin America. Lyndon Johnson, according to Stone, disregarded JFK’s “memo” about withdrawing troops and instead escalated. The Cataclysm in Vietnam as the war reaches a turning point - there's no going back. The betrayal by Richard Nixon.